A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism

NCT07470983 | Recruiting Phase 2

• 1 other identifier: HRS-1780-203
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

This study is a multicenter, randomized, double-blind, placebo-parallel-controlled phase II clinical trial to evaluate the efficacy and safety of HRS-1780 compared with placebo in participants with primary aldosteronism. The study plans to enroll 60 participants.

Conditions

Primary Aldosteronism

Outcome Measures

Primary Outcomes (1)

• Change from baseline in office systolic blood pressure (SBP);

  up to Week 8

Secondary Outcomes (10)

• Rate of achieving office blood pressure <140/90 mmHg;

  up to Week 8

• Rate of achieving office blood pressure <130/80 mmHg;

  up to Week 8

• Change from baseline in office diastolic blood pressure (DBP) ;

  up to Week 8

• Change from baseline in 24-hour ambulatory blood pressure monitoring (ABPM) mean SBP and DBP ;

  up to Week 8

• Change from baseline in 24-hour ABPM daytime and nighttime SBP and DBP ;

  up to Week 8

Study Arms (2)

HRS-1780 Tablets

EXPERIMENTAL

Drug: HRS-1780 Tablets

Placebo

PLACEBO COMPARATOR

Drug: Placebo

Interventions

HRS-1780 Tablets DRUG

HRS-1780 Tablets

HRS-1780 Tablets

Placebo DRUG

Placebo

Placebo

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female, aged ≥ 18 years on the date of signing the informed consent form.
• Diagnosed with primary aldosteronism.
• No use of antihypertensive drugs before screening, or stable use of antihypertensive drugs.
• Voluntarily sign the informed consent form before the trial, fully understand the trial content, procedures, and possible adverse reactions, and be capable and willing to comply with the protocol requirements to complete the study.
• From the signing of the informed consent form until 4 weeks after the last dose, the participant has no plan for procreation and is willing to adopt the highly effective contraceptive measures specified in the protocol.

You may not qualify if:

• Has known secondary causes of hypertension.
• Has previously undergone, or plans to undergo during the study period, adrenal-related surgeries, including adrenalectomy, adrenal ablation, etc.
• Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m².
• Has had any malignancy of an organ system within 5 years before screening.
• Has received any other investigational drug within 90 days or 5 half-lives before screening (whichever is longer).
• Has a history of blood donation or blood loss ≥ 400 mL within 3 months before screening, or has received a blood transfusion within 2 months.
• Known or suspected alcohol or narcotic abuse.
• Women who are pregnant, breastfeeding, planning pregnancy, or of childbearing potential unable to adopt highly effective contraceptive measures; or men unable to adopt highly effective contraceptive measures.
• Abnormal daily routine.
• Use of strong inhibitors/inducers of cytochrome P450 3A4 (CYP3A4) within 1 week before randomization.
• Severe infection, severe trauma, or major or medium-scale surgery within 1 month prior to screening;
• Stroke, transient ischemic attack, myocardial infarction, symptomatic heart failure (NYHA III-IV), or coronary revascularization within 3 months prior to screening; and/or planned coronary, carotid, or peripheral artery revascularization at the time of screening;
• Within 6 months prior to the screening period, participants have clinically significant diseases that, in the judgment of the investigator, may interfere with the trial results or pose additional risks to the administration of the study drug, including but not limited to respiratory, digestive, cardiovascular, endocrine, immune, urinary, adrenal (except for the primary disease), hematological, neurological, psychiatric, or other conditions;
• Presence or suspected presence of depression, bipolar disorder, suicidal tendencies, schizophrenia, or other severe mental disorders; or participants with mental incapacity or language barriers that prevent them from adequately understanding or participating in the trial process;
• Alanine aminotransferase (ALT) ≥ 3 × upper limit of normal (ULN);

Sponsors & Collaborators

• Shandong Suncadia Medicine Co., Ltd.: lead

Study Sites (2)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

RECRUITING

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China

RECRUITING

MeSH Terms

Conditions

Hyperaldosteronism

Condition Hierarchy (Ancestors)

Adrenocortical Hyperfunction; Adrenal Gland Diseases; Endocrine System Diseases

Central Study Contacts

Shenhuan Liu

CONTACT

0518-82342973; shenhuan.liu@hengrui.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2026
• First Posted: March 13, 2026
• Study Start: April 23, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-03

Locations

CN (2)