Role of High-Frequency Oscillations on Scalp EEG in Identifying Epileptogenic Activity in Patients With Epilepsy and Healthy Controls

NCT07470931 | Completed

• 1 other identifier: 2020/11-26
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.

Conditions

Epilepsies

Outcome Measures

Primary Outcomes (1)

• Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG

  The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.

  At the time of EEG assessment / baseline

Study Arms (2)

epilepsy patients

epileptic patients with eeg

normal control

non epileptic patients with eeg

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with epilepsy and age- and sex-comparable healthy controls who underwent scalp EEG recording. The control group consisted of individuals referred to the EEG laboratory for syncope differential diagnosis and found suitable for inclusion as controls.

You may qualify if:

• Adults diagnosed with epilepsy
• Availability of routine awake scalp EEG recording suitable for analysis
• EEG recorded with the study protocol and technical specifications
• Adults without epilepsy
• Referred for EEG evaluation in the context of syncope differential diagnosis
• Scalp EEG recording suitable for analysis

You may not qualify if:

• EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis
• Individuals not meeting study group definitions

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

Saglik Bilimleri University Izmir Faculty of Medicine Department of Neurology

Izmir, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2026
• First Posted: March 13, 2026
• Study Start: March 1, 2023
• Primary Completion: September 30, 2023
• Study Completion: September 30, 2023
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)