Structural and Functional Connectivity in Partial Epilepsies Studied with MRI and MEG

NCT01313260 | Completed DMC

• 2 other identifiers: C09-212010-A00399-30
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated focus but surgical benefits are less clear for patients with a poorly defined focus such as non lesional refractory partial epilepsies. SEEG is considered the criterion standard to localize the epileptogenic zone (EZ) but the procedure is risky with a limited spatial sampling. The development of non-invasive neuroimaging alternatives is thus an important goal to improve EZ delineation and optimize SEEG procedures. The main hypothesis of this research project is the existence of a network organization specific for each patient which allows the generation and propagation of epileptic activities. The investigators wish to explore this network using diffusion tensor MRI to study structural connectivity and MEG/FMRI to study functional connectivity. The investigators will apply tools from the theories of complex networks and dynamical systems to characterize the network organization of epileptic process. The investigators aimed to identify and localize differences in connectivity parameters between individual patients and a control group of healthy volunteers.

Conditions

Epilepsies

Keywords

Refractory partial epilepsies

Outcome Measures

Primary Outcomes (1)

• Epileptic network assessed using structural and functional connectivity measures obtained with MRI and MEG

  Structural connectivity will be assessed using diffusion tensor MRI including the following parameters: mean diffusivity and anisotropy at voxel level, fiber tractography. Functional connectivity will be assessed using Rs-FMRI or MEG signal correlation measures. Cortical parcellation will allow the location of connectivity parameters calculated using the graph theory. Structural and functional data from one given patient will be statistically compared those of the control group.

  one year

Study Arms (2)

Epilepsy patients

Epilepsy patients selected before undergoing intracranial EEG recordings

control group

Healthy volunteers

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Refractory partial epilepsy patients

You may qualify if:

• intracranial EEG recordings scheduled
• no neurological or psychiatric disease for healthy volunteers

You may not qualify if:

• contraindication to MRI
• pregnancy

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

ICM (Brain and Spine Institute)

Paris, 75013, France

Location

Related Publications (1)

• Chavez M, Valencia M, Navarro V, Latora V, Martinerie J. Functional modularity of background activities in normal and epileptic brain networks. Phys Rev Lett. 2010 Mar 19;104(11):118701. doi: 10.1103/PhysRevLett.104.118701. Epub 2010 Mar 18.

  PMID: 20366507 BACKGROUND

Related Links

• Organization

MeSH Terms

Conditions

Epilepsy; Epilepsies, Partial

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 15, 2011
• First Posted: March 11, 2011
• Study Start: April 5, 2011
• Primary Completion: October 1, 2013
• Study Completion: October 1, 2013
• Last Updated: January 23, 2025

Record last verified: 2025-01

Locations

FR (1)