Optimisation of Solute Removal and Water Usage in Paediatric Haemodialysis

NCT07466459 | Enrolling By Invitation

• 1 other identifier: ONZ-2025-0402
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Children receiving chronic haemodialysis are typically treated with dialysis machines designed for adult patients. As a result, some devices do not allow the ideal blood or dialysate flow rates to be set for paediatric use. In addition, the optimal dialysate-to-blood flow ratio for maximising solute removal while minimising water consumption remains poorly defined. The aim of this study is to quantify the dialyser extraction ratio and clearance across different dialysis modalities and a range of dialysate-to-blood flow ratios. Blood and dialysate samples are collected at the blood inlet, blood outlet, and dialysate outlet lines, and concentrations of various uraemic toxins-spanning a range of molecular weights-are measured to calculate solute clearances.

Conditions

Pediatric; Efficiency; Hemodialysis Patient; Hemodialysis Treatment

Keywords

hemodialysis; dialyser clearance; water usage; extraction ratio; pediatric

Outcome Measures

Primary Outcomes (1)

• Extraction Ratio

  Extraction ratio is calculated from dialyzer inlet and outlet toxin concentrations for different dialysis settings. Dialysis efficiency, based on extration ratio, is related to the corresponding water usage.

  During the first hour of one midweek dialysis session, different dialysis flows and modalities are set for the time needed to take the samples.

Study Arms (1)

dialysis settings

EXPERIMENTAL

In each participant and in a consecutive way, different dialysis modalities and dialysate to blood flow ratios are set.

Other: blood and dialysate sampling

Interventions

blood and dialysate sampling OTHER

For ach setting, blood and dialysate samples are taken in order to be able to calculate the extraction ratio and dialyser clearance.

dialysis settings

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• not older than 18 years old
• at least three months of stable hemodialysis

You may not qualify if:

• a non well-functioning vascular access
• infections at the study week

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent University Hospital, Nephrology

Ghent, 9000, Belgium

Location

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: March 12, 2026
• Study Start: November 13, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 12, 2026

Record last verified: 2026-03

Locations

BE (1)