A Novel Approach in the Evaluation of Breast Masses With Doppler US

NCT07465523 | Recruiting

• 1 other identifier: 26-2025/22
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

In cases with breast masses, Doppler resistive index values will be calculated for the mass and surrounding healthy tissue and the opposite healthy breast tissue, and their effect on distinguishing between benign and malignant masses will be evaluated.

Conditions

Breast Neoplasm Female; Benign Breast Neoplasm; Malign Breast Neoplasm; Doppler Ultrasound Diagnosis

Keywords

Breast Mass; Doppler Ultrasound; B-Mode Ultrasound; Resistive Index

Outcome Measures

Primary Outcomes (1)

• A Novel Approach to the Evaluation of Breast Masses Using Doppler Ultrasonography: Percentage Changes in Resistive Index Between the Mass and Surrounding Normal Parenchyma in Benign-Malignant Differentiation

  ROC curve analysis will be applied for the diagnostic performance of relative RI change in benign and malignant lesions.

  3-4 months

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Since this study is a breast study, it will only be conducted on women.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of female patients over the age of 18 who underwent breast biopsy in the radiology department due to a solid lesion in the breast.

You may qualify if:

• Those with solid breast masses
• Female patients
• Those with pathology results

You may not qualify if:

• Hypovascular masses
• Cystic breast masses
• Cases with mastitis

Sponsors & Collaborators

• Ahmet Yesildag: lead

Study Sites (1)

Karamanoğlu Mehmetbey University, KEAH

Karaman, Lütfen Seçiniz., 70200, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Choi HY, Kim HY, Baek SY, Kang BC, Lee SW. Significance of resistive index in color Doppler ultrasonogram: differentiation between benign and malignant breast masses. Clin Imaging. 1999 Sep-Oct;23(5):284-8. doi: 10.1016/s0899-7071(99)00152-7.

  PMID: 10665344 BACKGROUND

• Niu J, Ma J, Guan X, Zhao X, Li P, Zhang M. Correlation Between Doppler Ultrasound Blood Flow Parameters and Angiogenesis and Proliferation Activity in Breast Cancer. Med Sci Monit. 2019 Sep 19;25:7035-7041. doi: 10.12659/MSM.914395.

  PMID: 31535669 BACKGROUND

• Mehta TS, Raza S, Baum JK. Use of Doppler ultrasound in the evaluation of breast carcinoma. Semin Ultrasound CT MR. 2000 Aug;21(4):297-307. doi: 10.1016/s0887-2171(00)90024-6.

  PMID: 11014252 BACKGROUND

Study Officials

• Ahmet Yeşildağ, Prof.Dr.

  Karamanoğlu Mehmetbey Universty

  STUDY DIRECTOR

• Ahmet Yeşildağ, Prof.Dr.

  Karamanoğlu Mehmetbey University

  STUDY DIRECTOR

Central Study Contacts

Ahmet Yeşildağ, Prof.Dr

CONTACT

+905057728297; ahmetysd@hotmail.com

Gökçe Merve Arman, Dr.

CONTACT

+905058734762; gmerveturgut@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: March 6, 2026
• First Posted: March 12, 2026
• Study Start: March 4, 2026
• Primary Completion: May 5, 2026
• Study Completion: May 19, 2026
• Last Updated: March 16, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)