Effects of Music Therapy on Anxiety and Distress Levels During Radionuclide Treatment in Prostate Cancer Patients

NCT07464964 | Completed

• 1 other identifier: DokuzEU-SBE-EUT-02
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This interventional study aimed to evaluate the effects of music therapy on anxiety and distress levels in patients with prostate cancer undergoing radionuclide therapy. A total of 60 patients who met the eligibility criteria were included in the study. Participants were assigned to either an intervention group or a control group. Patients in the intervention group listened to music through headphones during the radionuclide treatment session, while patients in the control group received standard care without a music intervention. Music selections included various types of non-verbal music such as classical music, Turkish classical music, and other instrumental genres. Participants were allowed to select their preferred music from a predefined list. Psychological distress and anxiety levels were assessed using the Distress Thermometer and the Hospital Anxiety and Depression Scale. Measurements were obtained before the treatment session and again after completion of the radionuclide therapy. The study evaluated whether listening to music during treatment could reduce anxiety and distress levels in patients receiving radionuclide therapy for prostate cancer.

Conditions

Anxiety; Music Therapy; Prostate Cancer (Diagnosis); Psychological Distress

Keywords

Music Therapy; Radionuclide Therapy; Prostate Cancer; Anxiety; Distress

Outcome Measures

Primary Outcomes (1)

• Change in Anxiety Level

  Anxiety levels were assessed using the Hospital Anxiety and Depression Scale (HADS). The scale was administered before radionuclide therapy and again after completion of the treatment session to evaluate changes in anxiety levels between the intervention and control groups.

  Baseline (before radionuclide therapy) and immediately after completion of each radionuclide therapy session, assessed over three treatment cycles

Secondary Outcomes (1)

• Change in Psychological Distress Level

  Baseline (before radionuclide therapy) and immediately after completion of each radionuclide therapy session, assessed over three treatment cycles

Study Arms (2)

Music Therapy Group

EXPERIMENTAL

Patients in this group listened to self-selected instrumental music through headphones during radionuclide therapy. The music was chosen according to the patient's preference from a categorized list of non-verbal music types. Music was played for approximately 20-40 minutes during the treatment session.

Behavioral: Music Therapy

control group

NO INTERVENTION

Patients in this group received standard care during radionuclide therapy without any music intervention. Anxiety and distress levels were assessed using the same measurement tools as in the intervention group.

Interventions

Music Therapy BEHAVIORAL

Listening to instrumental music through headphones during radionuclide therapy for approximately 20-40 minutes based on patient preference.

Music Therapy Group

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Dokuz Eylul University Hospital

Izmir, Balçova, 35330, Turkey (Türkiye)

Location

Related Publications (4)

• Rennie C, Irvine DS, Huang E, Huang J. Music Therapy as a Form of Nonpharmacologic Pain Modulation in Patients with Cancer: A Systematic Review of the Current Literature. Cancers (Basel). 2022 Sep 11;14(18):4416. doi: 10.3390/cancers14184416.

  PMID: 36139576 BACKGROUND

• Valero-Cantero I, Casals C, Espinar-Toledo M, Baron-Lopez FJ, Martinez-Valero FJ, Garcia-Agua Soler N, Vazquez-Sanchez MA. Effect of Self-Chosen Music in Alleviating the Burden on Family Caregivers of Patients with Advanced Cancer: A Randomised Controlled Trial. Int J Environ Res Public Health. 2023 Mar 6;20(5):4662. doi: 10.3390/ijerph20054662.

  PMID: 36901671 BACKGROUND

• Begovac J, Kuzmanovic N, Bejuk D. Comparison of clinical characteristics of group A streptococcal bacteremia in children and adults. Clin Infect Dis. 1996 Jul;23(1):97-100. doi: 10.1093/clinids/23.1.97.

  PMID: 8816136 BACKGROUND

• He H, Li Z, Zhao X, Chen X. The effect of music therapy on anxiety and pain in patients undergoing prostate biopsy: A systematic review and meta-analysis. Complement Ther Med. 2023 Mar;72:102913. doi: 10.1016/j.ctim.2022.102913. Epub 2022 Dec 26.

  PMID: 36581055 BACKGROUND

MeSH Terms

Conditions

Anxiety Disorders; Prostatic Neoplasms; Disease

Interventions

Music Therapy

Condition Hierarchy (Ancestors)

Mental Disorders; Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Sensory Art Therapies; Complementary Therapies; Therapeutics; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Ezgi Karadağ, Prof

  Dokuz Eylul University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants were assigned to either an intervention group or a control group using a sequential allocation method. Patients in the intervention group listened to music during radionuclide therapy, while patients in the control group received standard care without music intervention. Anxiety and distress levels were measured before and after the treatment session.

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: March 11, 2026
• Study Start: September 1, 2023
• Primary Completion: September 30, 2025
• Study Completion: September 30, 2025
• Last Updated: March 11, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)