Changes in Scalp Condition After Using a Moisturizer: a Prospective Clinical Trial Using Artificial Intelligence

NCT07459023 | Completed

• 1 other identifier: B-2504-964-001
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate whether a scalp moisturizer containing celastrol and Cichorium intybus root extract can improve scalp condition in adults aged 19 years or older who require scalp moisturization due to dryness, scaling, erythema, or dandruff. The main questions it aims to answer are: Does once-daily application of the study moisturizer improve scalp condition from baseline to week 4, as assessed by SPI-AI (Scalp Photographic Index-Artificial Intelligence)? Does the moisturizer improve scalp biophysical parameters (erythema index, stratum corneum hydration, and transepidermal water loss) and patient-reported symptom severity over the 4-week treatment period? Participants will: Apply the study moisturizer once daily at bedtime to dry scalp for 4 weeks and rinse it off the following morning using their usual shampoo. Attend study visits at baseline (week 0), week 2, and week 4 for scalp imaging, biophysical measurements, symptom questionnaires, adherence assessment, and safety monitoring.

Conditions

Dandruff; Seborrhoeic Dermatitis of the Scalp

Keywords

scalp discomfort; scalp erythema; scalp dryness; scalp scaling; scalp pruritus

Outcome Measures

Primary Outcomes (1)

• SPI-AI

  Scalp Photographic Index with artificial intelligence

  4week

Secondary Outcomes (9)

• SPI-AI

  2week

• Biophysical parameter

  2week

• Biophysical parameter

  4week

• Biophysical parameter

  2 week

• Biophysical parameter

  4 week

Study Arms (1)

Moisturizer

ACTIVE COMPARATOR

participants applies the moisturizer once daily to the entire scalp at bedtime

Other: Ducray Kertyol P.S.O. Concentrate Cream, Ducray Laboratory, France

Interventions

Ducray Kertyol P.S.O. Concentrate Cream, Ducray Laboratory, France OTHER

participants applied the moisturizer once daily to the entire scalp at bedtime

Moisturizer

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥19 years
• Presence of scalp erythema, dryness, scaling, or dandruff requiring scalp moisturization

You may not qualify if:

• Active infectious scalp dermatoses
• Use of topical or systemic therapies affecting scalp status within 4 weeks prior to enrollment or during the study period
• Inability to comply with the study protocol

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam-si, Kyeonggi, South Korea

Location

MeSH Terms

Conditions

Dandruff

Condition Hierarchy (Ancestors)

Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Scalp Dermatoses

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: February 26, 2026
• First Posted: March 9, 2026
• Study Start: July 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: March 9, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)