NCT05319444

Brief Summary

The objective of this study is to evaluate an improvement of scalp health after the use of an investigational off-label WaterPik and brush device aimed to massage and cleanse the scalp.

Trial Health

53
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial recruitment is currently suspended
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
6mo left

Started May 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
suspended

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress4%
May 2026Nov 2026

First Submitted

Initial submission to the registry

March 31, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 8, 2022

Completed
4.1 years until next milestone

Study Start

First participant enrolled

May 1, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2026

Last Updated

December 17, 2025

Status Verified

December 1, 2025

Enrollment Period

6 months

First QC Date

March 31, 2022

Last Update Submit

December 11, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Adherent Scalp Flaking Scale (ASFS)

    The presence of dandruff flakes adhereing to the scalp in 8 defined areas is rated on a scale of 0-10 per area, where 0 indicates no flakes and 10 indicates heavy flaking. This is combined for total scores ranging from 0-80.

    4 weeks

Secondary Outcomes (2)

  • Change in Erythema Score

    4 weeks

  • Change in Patient Sensory Assessment of Scalp & Hair Score

    4 weeks

Study Arms (8)

Healthy Scalp and one treatment

EXPERIMENTAL

Participants with healthy scalps who will receive one treatment with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Healthy Scalp and three treatments

EXPERIMENTAL

Participants with healthy scalps who will receive three treatments with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Dandruff and one treatment

EXPERIMENTAL

Participants with dandruff who will receive one treatment with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Dandruff and three treatments

EXPERIMENTAL

Participants with dandruff who will receive three treatments with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Hair loss disease and one treatment

EXPERIMENTAL

Participants with hair loss disease who will receive one treatment with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Seborrheic Dermatitis with one treatment

EXPERIMENTAL

Participants with seborrheic dermatitis disease who will receive one treatment with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Seborrheic Dermatitis and three treatments

EXPERIMENTAL

Participants with seborrheic dermatitis who will receive three treatments with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Hair loss disease and three treatments

EXPERIMENTAL

Participants with hair loss disease who will receive three treatments with the device and complete one in-person follow-up.

Device: Off-brand Waterpik®

Interventions

Study staff will use the Waterpik® device and brush for approximately two to five minutes on the participant's scalp until all scale and other debris appears to be resolved. Their scalp will then be rinsed and gently dried with a towel. The off-label design utilizes the Waterpik® device, but with adjustments optimized for scalp health. The device settings are adjustable during the treatment, ranging from settings of 2-10. Study staff plan to utilize the setting of 10 unless the participant indicates discomfort. Investigators attached a small Losophy brush in replacement of the Waterpik® toothbrush. The small Losophy brush was connected to the device via PVC heat shrink and a hole was drilled on the brush in order to deliver water while simultaneously utilizing the brush on the scalp.

Dandruff and one treatmentDandruff and three treatmentsHair loss disease and one treatmentHair loss disease and three treatmentsHealthy Scalp and one treatmentHealthy Scalp and three treatmentsSeborrheic Dermatitis and three treatmentsSeborrheic Dermatitis with one treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants must qualify for one of the following scalp conditions based on clinical opinion of a board-certified dermatologist: healthy scalp, dandruff, seborrheic dermatitis, or hair loss disease
  • All Women of Child Bearing Potential must indicate use of two of the following contraceptive methods. The WaterPik device uses an ultrasonic technology which includes ultrasound. Unnecessary ultrasound is not recommended for pregnant women.
  • Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal)
  • Progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable)
  • Intrauterine device (IUD)
  • Intraurerine hormone-releasing system (IUS)
  • Vasectomized partner
  • Sexual abstinence
  • Barrier method, such as a condom

You may not qualify if:

  • Non-English speaking
  • Current clinical condition that, in the opinion of the site investigator, would interfere with adherence to study requirements

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

MeSH Terms

Conditions

DandruffDermatitis, SeborrheicAlopecia

Condition Hierarchy (Ancestors)

DermatitisSkin DiseasesSkin and Connective Tissue DiseasesScalp DermatosesSebaceous Gland DiseasesSkin Diseases, EczematousSkin Diseases, PapulosquamousHypotrichosisHair DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Officials

  • Ronda Farah, MD

    University of Minnesota Medical School Department of Dermatology

    PRINCIPAL INVESTIGATOR
  • Maria Hordinsky, MD

    University of Minnesota Medical School Department of Dermatology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 31, 2022

First Posted

April 8, 2022

Study Start

May 1, 2026

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

November 1, 2026

Last Updated

December 17, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations