Trials Sponsors Conditions Drugs Pricing

Conditions

Achalasia, Esophageal Esophagogastric Junction Outflow Obstruction Spastic Esophageal Disorders

Outcome Measures

Primary Outcomes (3)

Distensibility
FLIP Imaging EGJ metric Distensibility at 60 mL fill volume
at 10 min
Diameter
FLIP Imaging EGJ metric Diameter
at 10 min
Contractile Response
Contractile response category
at 10 min

Secondary Outcomes (1)

EGJ opening category
at 10 min

Study Arms (3)

propofol-propofol

PLACEBO COMPARATOR

This is the control comparison of a subject undergoing FLIP imaging under the baseline scenario of propofol alone and then the again for a second time under propofol alone.

Diagnostic Test: FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.

propofol-SEVO

ACTIVE COMPARATOR

This is the the study comparison group of a subject undergoing FLIP imaging under the baseline scenario of propofol alone and then the again for a second time but this time under the anesthetic gas sevofluorane.

Diagnostic Test: FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.

propofol-ISO

ACTIVE COMPARATOR

Interventions

FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.Diagnostic test

FLIP imaging will occur twice per subject with the same baseline (propofol) assessment and then a second study assessment with propofol, sevofluorane, or isofluorane.

propofol-ISOpropofol-SEVOpropofol-propofol

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 75 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Study subjects will include male and female patients age ≥18 to 75 years with dysphagia caused by achalasia (Type I, II or III) or by EGJ-outflow obstruction, suspected motility disorder, or undergoing an endoscopy to rule out an esophageal motility disorder who have been seen by Drs. Konda, Spechler, Nguyen, Reddy, Ellison, or Podgaetz. These patients will be undergoing an endoscopy and POEM procedure.

You may not qualify if:

Sponsors & Collaborators

Baylor Research Institute
Otherlead

Study Sites (1)

Baylor University Medical Center - Jonsson Building

Dallas, Texas, 75246, United States

Related Publications (9)

Benitez A, Jablonka DH, Sahu V, Gluckman C, DeMarshall M, Ostapenko S, Falk GW, Lynch KL, Menard-Katcher CD, Muir AB. Sevoflurane influences esophagogastric junction distensibility in the absence of esophageal inflammation. Gastrointest Endosc 2019; 89: AB 635,Tu 1968
BACKGROUND
Wellington J, Kim GE, Yang AH, Hwang DG, Kim RE. Effect of Anesthetics during endoflip impacts diagnosis of esophageal motility disorders. Gastrointest Endosc; 2020; 91: AB 133, Sa 1253
BACKGROUND
Donnan EN, Pandolfino JE. EndoFLIP in the Esophagus: Assessing Sphincter Function, Wall Stiffness, and Motility to Guide Treatment. Gastroenterol Clin North Am. 2020 Sep;49(3):427-435. doi: 10.1016/j.gtc.2020.04.002. Epub 2020 Jun 14.
PMID: 32718562BACKGROUND

MeSH Terms

Conditions

Esophageal Achalasia

Condition Hierarchy (Ancestors)

Esophageal Motility DisordersDeglutition DisordersEsophageal DiseasesGastrointestinal DiseasesDigestive System Diseases

Study Officials

Vani A Konda, MD
Baylor Health Care System
PRINCIPAL INVESTIGATOR

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Purpose: DIAGNOSTIC
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: MD

Study Record Dates

First Submitted

March 4, 2026

First Posted

March 9, 2026

Study Start

November 22, 2024

Actual (reported)

Primary Completion

July 2026

Estimated (date passed)

The Impact of Anesthetics on FLIP

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (1)

Study Arms (3)

propofol-propofol

propofol-SEVO

propofol-ISO

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (9)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (1)

Study Arms (3)

propofol-propofol

propofol-SEVO

propofol-ISO

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (9)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

Source record

Locations