Effect of Missed Dialysis Sessions on Short Term Cardiovascular Events

NCT07455799 | Not Yet Recruiting

• 1 other identifier: Missed HD sessions
• Study Type: observational
• Target: 225
• Locations: 1 country
• Sites: 1

Brief Summary

the effect of missed hemodialysis sessions on the occurrence of short-term cardiovascular events in patients with end-stage renal disease receiving maintenance hemodialysis.

Conditions

End Stage Renal Failure, Hemodialysis

Keywords

Renal failure; Missed sessions of HD

Outcome Measures

Primary Outcomes (1)

• Incidence of short-term cardiovascular events (CVE) following missed hemodialysis sessions

  Short-term cardiovascular events will be defined as the occurrence of acute coronary syndrome, acute decompensated heart failure, documented arrhythmias, sudden cardiac death, or cerebrovascular events occurring within 72 hours after a missed hemodialysis session.

  1 year

Interventions

Electrocardiography (ECG) and Echocardiography (ECHO) DEVICE

A standard 12-lead ECG will be performed for all patients within 72 hours after a missed hemodialysis session to detect abnormalities.Transthoracic echocardiography will be performed as a baseline assessment for all enrolled patients using routine institutional protocols. Repeat echocardiographic examination will be performed only if clinically indicated,Echocardiographic parameters assessed will include left ventricular ejection fraction , left ventricular hypertrophy, regional wall motion abnormalities, diastolic function, and right ventricular function

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hemodialysis Unit of Internal Medicine Department

You may qualify if:

• Adult patients aged ≥18 years.
• Patients diagnosed with end-stage renal disease (ESRD).
• Patients receiving maintenance hemodialysis on a regular schedule (three sessions per week).
• Patients on maintenance hemodialysis for at least 3 months prior to enrolment.

You may not qualify if:

• Patients receiving peritoneal dialysis or other forms of renal replacement therapy.
• Patients with acute kidney injury requiring temporary dialysis.
• Patients with documented acute cardiovascular events within 30 days prior to study enrolment.
• Patients who undergo renal transplantation during the study period.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University Hospital

Asyut, Assiut Governorate, Egypt

Location

Related Publications (11)

• Kumar P, Savant K, Balakrishnan A, Nair S, Prabhu Attur R. Impact of Interdialytic Intervals on Sudden Cardiac Death in Chronic Kidney Disease Stage 5D Patients on a Twice-Weekly Hemodialysis Schedule. Kidney Blood Press Res. 2025;50(1):420-428. doi: 10.1159/000546184. Epub 2025 May 7.

  PMID: 40334646 RESULT

• Zhang Y, Wang J, Xing Y, Cui C, Cheng H, Chen Z, Chen H, Liu C, Wang N, Chen M. Dynamics of Cardiac Autonomic Responses During Hemodialysis Measured by Heart Rate Variability and Skin Sympathetic Nerve Activity: The Impact of Interdialytic Weight Gain. Front Physiol. 2022 May 16;13:890536. doi: 10.3389/fphys.2022.890536. eCollection 2022.

  PMID: 35651871 RESULT

• Lim K, Nayor M, Arroyo E, Burney HN, Li X, Li Y, Shah R, Campain J, Wan D, Ting S, Hiemstra TF, Thadhani R, Moe S, Zehnder D, Larson MG, Vasan RS, Lewis GD. Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction. Clin J Am Soc Nephrol. 2024 Dec 1;19(12):1547-1561. doi: 10.2215/CJN.0000000000000548. Epub 2024 Oct 14.

  PMID: 39401313 RESULT

• Canaud B, Kooman JP, Selby NM, Taal M, Maierhofer A, Kopperschmidt P, Francis S, Collins A, Kotanko P. Hidden risks associated with conventional short intermittent hemodialysis: A call for action to mitigate cardiovascular risk and morbidity. World J Nephrol. 2022 Mar 25;11(2):39-57. doi: 10.5527/wjn.v11.i2.39.

  PMID: 35433339 RESULT

• Fatovic-Ferencic S, Holubar K. The portrait and paper of a forgotten hero--Luca Stulli (1772-1828) and the Mal de Meleda of yesteryear: a 175-year anniversary. J Invest Dermatol. 2001 Jan;116(1):198-9. doi: 10.1046/j.1523-1747.2001.00225.x. No abstract available.

  PMID: 11168819 RESULT

• Hospice nursing. A special calling. Nursing. 1997 Jan;27(1):52-7. No abstract available.

  PMID: 9016084 RESULT

• Matise MP, Joyner AL. Gli genes in development and cancer. Oncogene. 1999 Dec 20;18(55):7852-9. doi: 10.1038/sj.onc.1203243.

  PMID: 10630638 RESULT

• Williams P, Keshavarz-Moore E, Dunnill P. Production of cadmium sulphide microcrystallites in batch cultivation by Schizosaccharomyces pombe. J Biotechnol. 1996 Jul 31;48(3):259-67. doi: 10.1016/0168-1656(96)01520-9.

  PMID: 8862002 RESULT

• Stuard S, Maddux FW, Canaud B. Why High-Volume Post-Dilution Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms. J Clin Med. 2025 Jul 9;14(14):4860. doi: 10.3390/jcm14144860.

  PMID: 40725552 RESULT

• Marinetti MT. Health workforce shortage in the United Kingdom and prospects of personnel recruitment from abroad. Cah Sociol Demogr Med. 2003;43(1):71-114. No abstract available.

  PMID: 12693356 RESULT

• Francis A, Harhay MN, Ong ACM, Tummalapalli SL, Ortiz A, Fogo AB, Fliser D, Roy-Chaudhury P, Fontana M, Nangaku M, Wanner C, Malik C, Hradsky A, Adu D, Bavanandan S, Cusumano A, Sola L, Ulasi I, Jha V; American Society of Nephrology; European Renal Association; International Society of Nephrology. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol. 2024 Jul;20(7):473-485. doi: 10.1038/s41581-024-00820-6. Epub 2024 Apr 3.

  PMID: 38570631 RESULT

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Renal Insufficiency

Interventions

Electrocardiography; Echocardiography

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Cardiac Imaging Techniques; Diagnostic Imaging; Ultrasonography

Study Officials

• Mohamed Ali Touhami Ibrahim, Professor

  PRINCIPAL INVESTIGATOR

• Eman Mohamed Ibrahim Kamed Hussain, Assistant lecture

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amna Abdelnasser Taher, Resident

CONTACT

+01080583753; a01094597745@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician

Study Record Dates

• First Submitted: March 3, 2026
• First Posted: March 6, 2026
• Study Start (Estimated): October 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: March 16, 2026

Record last verified: 2026-03

Locations

EG (1)