Exploring Predictors of Quality of Life in Older Adults With End-Stage Kidney Disease Receiving In-Center Hemodialysis

NCT07129083 | Completed DMC

• 1 other identifier: BC-11716
• Study Type: observational
• Target: 111
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional observational study investigates the overall quality of life (QoL) in adults aged 65 and older receiving in-center hemodialysis. While health-related quality of life (HRQoL) is commonly used in nephrology, it may not fully reflect what matters most to older patients. Using the Amnestic Comparative Self-Assessment (ACSA) as the primary measure, this study explores key determinants of QoL and examines how it relates to existing HRQoL tools (EQ-5D-3L, EORTC QLQ-C30, QLQ-MY20). Data are collected from four hospitals in Flanders, Belgium, using psychosocial (geriatric) assessments. Statistical analysis includes regression and cluster methods to identify predictors and patient subgroups. Results aim to inform more patient-centered care and improve QoL measurement in dialysis research.

Conditions

End Stage Renal Failure, Hemodialysis

Keywords

End-stage Kidney Disease; Hemodialysis; Quality of Life; Older Adults

Outcome Measures

Primary Outcomes (1)

• Quality of Life - Amnestic Comparative Self-Assessment (ACSA)

  A self-anchoring Quality of Life scale ranging from -5 (worst time in life) to +5 (best time in life). Participants reflect on their personal best and worst life periods and rate their current QoL accordingly.

  Baseline

Secondary Outcomes (18)

• Age

  Baseline

• Marital status

  Baseline

• Living situation

  Baseline

• (Grand)children

  Baseline

• Dialysis vintage

  Baseline

Study Arms (1)

Older adults receiving in-center hemodialysis

Adults aged 65 years and older undergoing maintenance in-center hemodialysis at four hospitals in Flanders, Belgium. Participants completed structured assessments covering overall quality of life, health-related quality of life, clinical, functional, psychological, and sociodemographic variables.

Other: Structured assessment interview

Interventions

Structured assessment interview OTHER

Participants completed a structured, in-person assessment conducted during one to three dialysis sessions. The assessment included validated instruments to measure overall quality of life (ACSA), health-related quality of life (EQ-5D-3L, EORTC QLQ-C30, QLQ-MY20), and various clinical, psychological, functional, and sociodemographic factors.

Older adults receiving in-center hemodialysis

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adults with end-stage kidney disease undergoing maintenance in-center hemodialysis

You may qualify if:

• Age 65 years or older
• Receiving maintenance in-center hemodialysis (ICHD)
• Able to provide informed consent
• Sufficient cognitive capacity to understand and answer study questions
• Fluent in Dutch (able to complete assessments in Dutch)

You may not qualify if:

• Receiving ICHD due to an acute hospital admission (not chronic treatment)
• Documented diagnosis of severe psychiatric illness or severe cognitive impairment (e.g., dementia)
• Unable to understand or respond adequately to the questionnaire

Sponsors & Collaborators

• University Ghent: lead

Study Sites (1)

Ghent University Hospital

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dominique Van d Van de Velde, Doctorate

  University Ghent

  PRINCIPAL INVESTIGATOR

• Wim Van Biesen, Doctorate, MD

  University Ghent

  STUDY DIRECTOR

• Patricia De Vriendt, Doctorate

  University Ghent

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2025
• First Posted: August 19, 2025
• Study Start: January 1, 2018
• Primary Completion: December 30, 2018
• Study Completion: July 15, 2025
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)