Artificial Intelligence-Based Cognitive Training in Patients With Stroke

NCT07452276 | Recruiting FDA Device

• 1 other identifier: P.T.REC/012/006268
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study would answer the following question:Does AI application-based training improve cognitive function in Patients with Stroke? The aims of this study: To investigate the efficacy of AI application-based training on cognitive function in stroke patients.

Conditions

Stroke; Artifical Intelligence; Post-Stroke Cognitive Impairment (PSCI)

Outcome Measures

Primary Outcomes (1)

• Change in Cognitive Function

  Change in Global Cognitive Function Measured by the Montreal Cognitive Assessment (MoCA) Global cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA), a one-page, 30-point cognitive screening tool that evaluates attention, memory, executive function, language, visuospatial abilities, abstraction, calculation, and orientation. The test takes approximately 10 minutes to administer. Scores range from 0 to 30, with higher scores indicating better cognitive function. A score of less than 26 indicates cognitive impairment.

  Baseline and 6 weeks post-intervention

Study Arms (2)

AI-Based Cognitive Training

EXPERIMENTAL

Participants receive artificial intelligence-based cognitive training in stroke patients. The AI program is designed to target multiple cognitive domains including attention, memory, executive function, and processing speed.

Device: cognifit Mobile Application for Cognitive Training

Conventional Physical Therapy

ACTIVE COMPARATOR

Participants receive a conventional rehabilitation program consisting of aerobic exercises, relaxation exercises, and traditional paper-based cognitive exercises, in addition to standard physical therapy.

Behavioral: Conventional Cognitive Rehabilitation

Interventions

cognifit Mobile Application for Cognitive Training DEVICE

A structured artificial intelligence-based cognitive training program targeting attention, memory, executive function, and processing speed in patients with stroke. The program provides adaptive, individualized exercises based on participant performance.

AI-Based Cognitive Training

Conventional Cognitive Rehabilitation BEHAVIORAL

A structured conventional rehabilitation program consisting of aerobic exercises, relaxation exercises, and traditional paper-based cognitive exercises for patients with stroke. The duration and frequency of treatment are matched to the experimental group.

Conventional Physical Therapy

Eligibility Criteria

• Age: 45 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patient's age will range from 45- 60 years.
• Diagnosis of stroke in the chronic stage (≥3 months post-onset).
• Presence of cognitive impairment confirmed by a Montreal Cognitive Assessment (MoCA) score ≤ 26.
• Medically stable and able to follow instructions.
• patients with memory deficits following stroke

You may not qualify if:

• \- Patients will be excluded if they have:
• Severe visual, hearing, or speech impairments prevent participation.
• History of other neurological or psychiatric disorders.
• Unstable cardiovascular or systemic disease.
• Severe depression (Beck Depression Inventory \> 29).

Sponsors & Collaborators

• Omima Alaa Eldin Hussein: lead

Study Sites (1)

Physical therapy- Cairo University

Cairo, Egypt, 62517, Egypt

RECRUITING

MeSH Terms

Conditions

Stroke

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Central Study Contacts

Omima Alaa Eldin Hussein

CONTACT

+201207838324; omimaalaa27@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: March 5, 2026
• Study Start: January 1, 2026
• Primary Completion: February 1, 2026
• Study Completion: June 6, 2026
• Last Updated: March 5, 2026

Record last verified: 2026-01

Locations

EG (1)