Effects of Mobile Application-Based Cognitive Training Along With Aerobic Training

NCT07148453 | Completed

• 1 other identifier: 02165/ Umber un Nisa
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial will determine the effects of combining mobile application-based cognitive training with aerobic exercise on cognitive function and the effects of combining mobile application-based cognitive training with aerobic exercise on quality of life in post-stroke patients

Conditions

Stroke

Keywords

Stroke rehabilitation; cognitive impairment; Lumosity; brain training games

Outcome Measures

Primary Outcomes (4)

• Montreal Cognitive Assessment

  Brief cognitive function assessment tool consisting of 12 items. Visuospatial, executive functioning, short-term memory, attention/concentration/Working memory, Language and orientation. Normal Cognition= 26-30 Cognitive impairment: Mild=18-25, Moderate=10-17, Severe= under 10

  6 weeks

• Trail Making Test A and B

  Measure the cognitive function executive. In part A the patient draws lines to join numbered circles (1-25) to connect them in ascending order. In part B, the patient connects the circles alternating between numbers (1-13) and letters (A-L). Trail A; Average; 29 Sec Deficient; \>78 sec Rule of Thumb Most in 90 sec Trail B; Average; 75 sec Deficient; \>273 sec. Rule of Thumb Most in 3min

  6 weeks

• 6-Minute Walk Test (6MWT)

  Submaximal exercise test that assesses aerobic capacity and endurance by measuring the distance an individual can walk on a flat, hard surface in a period of 6 minutes. It reflects functional exercise performance and cardiovascular fitness. Commonly used in stroke rehabilitation to evaluate improvements in mobility and endurance.

  6 weeks

• Stroke Specific Quality of Life scale (SS-QOL)

  The self-reported questionnaire consists of 49 items across 12 domains. Mobility, Mood, Self-care, Cognition, Social roles, Upper extremity function, work, sleep, family roles, personality, Vision, and strength. Scoring based on a Likert scale ranging from 1-5.

  6 weeks

Study Arms (2)

Lumosity-based cognitive training + aerobic exercise

EXPERIMENTAL

The experimental group will receive training through a smartphone-based brain training program using the Lumosity app, as well as aerobic exercise on a bicycle ergometer for 18 sessions other days for 6 weeks, 3 times per week, every session for 40 minutes (20 minutes aerobic training on a stationary bicycle ergometer followed by 20 minutes for Lumosity training application on the smartphone).

Other: Experimental Group

Aerobics + Traditional mental exercises

ACTIVE COMPARATOR

The control group will participate in aerobic training on a bicycle ergometer as well as mental exercises for 18 sessions every other day for 6 weeks, 3 sessions/week, each for 40 minutes.

Other: Control Group

Interventions

Experimental Group OTHER

The experimental group will receive training through a smartphone-based brain training program using the Lumosity app, as well as aerobic exercise on a bicycle ergometer for 18 sessions other days for 6 weeks, 3 times per week, every session for 40 minutes (20 minutes aerobic training on a stationary bicycle ergometer followed by 20 minutes for Lumosity training application on the smartphone).

Lumosity-based cognitive training + aerobic exercise

Control Group OTHER

The control group will participate in aerobic training on a bicycle ergometer as well as mental exercises for 18 sessions every other day for 6 weeks, 3 sessions/week, each for 40 minutes

Aerobics + Traditional mental exercises

Eligibility Criteria

• Age: 30 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both males and females
• Patients aged 30-75 years
• Spasticity grade (1 to 1+) based on the modified Ashworth scale (MAS)
• Patients with CVA Education level: matriculation
• at least Single-event stroke patients,
• with a post-stroke duration of 3 to 18 months.
• Mild to moderate cognitive impairment with a score between 10-25 on MOCA

You may not qualify if:

• Patients with a history of recurrent stroke or hemiparesis caused by conditions other than stroke.
• Patients with severe cardiovascular issues (e.g., unstable angina, severe coronary artery disease, or untreated congestive heart failure).
• Patients with dementia, depression, visual or auditory impairments, and other neurological conditions (e.g., Multiple Sclerosis, Parkinson's disease) affecting cognition.
• Individuals on medications known to affect cognitive function.
• Patients with low educational levels (illiterate).

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Railway General Hospital

Islamabad, Punjab Province, 44000, Pakistan

Location

MeSH Terms

Conditions

Stroke; Cognitive Dysfunction

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Umber un Nisa, MS-NMPT*

  Riphah International Unversity

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 24, 2025
• First Posted: August 29, 2025
• Study Start: August 20, 2025
• Primary Completion: February 20, 2026
• Study Completion: February 20, 2026
• Last Updated: March 30, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)