Research on Real-time Proton Therapy Guidance Through Monitoring Proton Range Using All-digital PET

NCT07450560 | Active Not Recruiting DMC

• 1 other identifier: CRTOG2602
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The energy transport process of proton beams after entering biological tissue is observed online via proton knife fully digital PET. The dynamic changes of the delivered dose and action range of proton beams in biological tissue are analyzed, the proton dose distribution is reconstructed, and the energy and position of the targeted ablation by proton beams are determined, so as to realize in-beam online PET monitoring for proton therapy.

Conditions

Solid Tumor

Keywords

Proton Therapy; fully digital PET; in-beam online monitoring

Outcome Measures

Primary Outcomes (1)

• the trajectory and range of the proton beam within the human body

  the three-dimensional dynamic distribution of positron nuclides generated by proton beam irradiation

  1 day

Interventions

proton therapy RADIATION

proton therapy

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with solid tumors scheduled to receive proton therapy, with measurable lesions;

You may qualify if:

• Patients with solid tumors scheduled to receive proton therapy, with measurable lesions;
• Signed the informed consent form.

You may not qualify if:

• Patients with a history of radioactive seed implantation;
• Patients who cannot understand the purpose of treatment or are unwilling/unable to sign the informed consent form;

Sponsors & Collaborators

• Shuanghu Yuan: lead

Study Sites (1)

Anhui Provincial Hospital

Hefei, Anhui, 230001, China

Location

MeSH Terms

Interventions

Proton Therapy

Intervention Hierarchy (Ancestors)

Heavy Ion Radiotherapy; Radiotherapy; Therapeutics

Study Officials

• Xiaojing Wang, MD

  Anhui Provincial Cancer Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 21, 2026
• First Posted: March 4, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: March 10, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

CN (1)