Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in Healthy Older Men

NCT07449767 | Completed

• 1 other identifier: 2025/019
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial investigated the effects of a four-week moderate-intensity resistance training program on diaphragm thickness, hepatic fat density, and health-related quality of life in healthy community-dwelling older men aged 60-75 years. Thirty participants were randomly assigned to a resistance training group or control group. Diaphragm thickness and hepatic attenuation were assessed using non-contrast computed tomography, and quality of life was evaluated using the SF-12 questionnaire. The primary outcome was change in diaphragm thickness. Secondary exploratory outcomes included hepatic fat density and SF-12 physical and mental health scores.

Conditions

Older Men; Quality of Life; Fatty Liver; Resistance Training; Aging

Keywords

Older men; Quality of life; Fatty liver; Diaphragm thickness; Resistance training; Aging

Outcome Measures

Primary Outcomes (1)

• Diaphragm Thickness

  Diaphragm thickness measured in millimeters using non-contrast computed tomography at full inspiration.

  4 weeks

Secondary Outcomes (3)

• Hepatic Fat Density

  4 weeks

• SF-12 Physical Health Score

  4 weeks

• SF-12 Mental Health Score

  4 weeks

Study Arms (2)

Resistance Training Group (RT)

EXPERIMENTAL

Participants performed supervised resistance training three times per week for four weeks. Each session lasted 30-40 minutes and included: Lower body exercises (sit-to-stand, step-ups, glute bridge) Upper body exercises (wall push-ups, resistance band row, biceps curl) Core exercises Breathing exercises (diaphragmatic breathing, pursed-lip breathing) Warm-up protocol (10 minutes dynamic mobility) Intensity: Borg RPE 12-15 Rest interval: 60 seconds between sets

Behavioral: Resistance Training Group (RT); Other: Control

CONTROL

NO INTERVENTION

Participants maintained their usual daily routines without structured exercise intervention.

Interventions

Resistance Training Group (RT) BEHAVIORAL

Structured Moderate-Intensity Resistance Training

Resistance Training Group (RT)

Control OTHER

Participants maintained their usual daily routines without structured exercise intervention.

Resistance Training Group (RT)

Eligibility Criteria

• Age: 60 Years - 75 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male
• Age 60-75 years
• Community-dwelling and functionally independent
• No structured exercise program in past 6 months
• No musculoskeletal injury in past 6 months
• Ability to provide written informed consent
• Stable neuropsychological status

You may not qualify if:

• Chronic liver disease
• Uncontrolled cardiovascular or pulmonary disease
• Recent respiratory infection
• Use of medications affecting muscle or liver metabolism (e.g., systemic corticosteroids, anabolic agents, hepatotoxic drugs)
• Participation in structured exercise or respiratory training within past 6 months
• Unstable thyroid hormone replacement therapy

Sponsors & Collaborators

• Gümüşhane Universıty: lead

Study Sites (1)

Gumushane Univetsity

Gümüşhane, Trabzon, Ordu, Giresun, Rize, Artvin, Gümüşhane, 29600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Fatty Liver

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ASSOC. PROF.

Model Details: Resistance Training Group (RT) The RT group completed a supervised moderate-intensity resistance training program three times per week for four weeks (30-40 minutes/session, RPE 12-15). The control group maintained usual daily activities.

Study Record Dates

• First Submitted: February 27, 2026
• First Posted: March 4, 2026
• Study Start: June 10, 2025
• Primary Completion: July 25, 2025
• Study Completion: August 10, 2025
• Last Updated: March 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)