Dynamic and Isometric Strength Training in Older Adults With Hypertension

NCT07448818 | Recruiting

• 1 other identifier: DYNISO-HT
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Participants will be randomly assigned to one of the two training modalities and will complete supervised exercise sessions throughout the intervention period. The study will provide preliminary evidence regarding the safety, acceptability, and potential impact of each training modality on health outcomes in this population.

Conditions

Hypertension; Elderly (People Aged 65 or More)

Keywords

Hypertension; Strength training; Resistance training; Cardiovascular health; blood pressure; old age

Outcome Measures

Primary Outcomes (6)

• Recruitment rate

  Proportion of enrolled participants relative to the total number of eligible individuals contacted. Reported as a percentage.

  Baseline and 6 weeks

• Adherence to training sessions

  Percentage of completed training sessions relative to the total number of planned sessions over the 6-week intervention period.

  During 6 weeks

• Retention rate

  Proportion of participants who complete the full 6-week intervention

  During 6 weeks

• Fidelity to exercise protocol

  Percentage of exercises performed according to the prescribed protocol parameters, including load, repetitions, and time under tension.

  Duiring 6 weeks

• Acceptability of the intervention

  Acceptability assessed through a structured satisfaction questionnaire, scored from 0 to 10, administered at the end of the 6-week intervention

  During 6 weeks

• Occurrence of adverse events

  Number of intervention-related adverse events, classified as mild, moderate, or severe

  During 6 weeks

Secondary Outcomes (17)

• Change from baseline in Clinical resting blood pressure at 6 weeks

  Baseline and 6 weeks

• Change from baseline in Home blood pressure monitoring at 6 weeks

  Baseline and 6 weeks

• Change from baseline in Flow-mediated dilation at 6 weeks

  Baseline and 6 weeks

• Change from baseline in Standard deviation of normal R-R intervals at 6 weeks

  Baseline and 6 weeks

• Change from baseline in Arterial stiffness at 6 weeks

  Baseline and 6 weeks

Study Arms (3)

Dynamic Strength Training

ACTIVE COMPARATOR

The subjects randomized to this group will perform two supervised dynamic strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes.

Behavioral: Dynamic Strength Training

Isometric Strength Training

EXPERIMENTAL

The subjects randomized to this group will perform two supervised isometric strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes.

Behavioral: Isometric Strength Training

Control

OTHER

No supervised training will be provided. Participants in this group will not receive any exercise intervention during the 6-week study period, but they will be stimulated to be active.

Behavioral: No supervised intervention Control

Interventions

Dynamic Strength Training BEHAVIORAL

The experimental group will perform dynamic strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group movements, initially 2 sets of 15 repetitions (Borg 4-6), progressing to 3 sets of 10 repetitions (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for \~30 minutes at moderate intensity.

Dynamic Strength Training

Isometric Strength Training BEHAVIORAL

The experimental group will perform isometric strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group contractions, initially 2 sets of 60 seconds (Borg 4-6), progressing to 3 sets of 40 seconds (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for \~30 minutes at moderate intensity.

Isometric Strength Training

No supervised intervention Control BEHAVIORAL

This group serves as a control and will not perform any structured exercise program.

Control

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of arterial hypertension and currently taking antihypertensive medication
• Age 60 years or older
• Resting blood pressure below 160/95 mmHg
• No high cardiovascular risk according to the American College of Sports Medicine criteria (for participants with type 2 diabetes, glycemic control with fasting glucose \<100 mg/dL and postprandial glucose \<140 mg/dL)
• Not participating in a structured exercise program for more than three months
• No cognitive or functional limitations that prevent participation in the exercise program

You may not qualify if:

• Presence of acute illnesses, such as influenza, sinusitis, gastroenteritis, urinary tract infection, fever, inflammatory processes, or any clinical condition requiring rest or that may compromise safety during assessments or training.
• Decompensated clinical conditions, including: Blood pressure spikes, Chest pain, Uncontrolled arrhythmias, Shortness of breath at rest, Asthma exacerbations, Decompensated diabetes mellitus, characterized by Persistently elevated blood glucose levels (fasting glucose \> 180 mg/dL or postprandial glucose \> 250 mg/dL)
• Irregular use of medication
• Any unstable clinical condition or condition that represents additional risk for the practice of physical exercise.

Sponsors & Collaborators

• Raphael Mendes Ritti Dias: lead

Study Sites (1)

Uninove

São Paulo, São Paulo, 01525-000, Brazil

RECRUITING

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Raphael M Ritti-Dias, PhD

  University of Nove de Julho

  STUDY CHAIR

Central Study Contacts

Adão Luis Monte L Monte, Ms

CONTACT

+55 11 94666 5213; adaoluiz8@outlook.com

Raphael M Ritti-Dias, PhD

CONTACT

+5519999406878; raphaelritti@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: February 16, 2026
• First Posted: March 4, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be shared adter the publication of the main trial
• Access Criteria: Will be avaliable in open repositories

Locations

BR (1)