NCT07447011

Brief Summary

glaucoma is prevalent among obstructive sleep apnea (OSA). contnous passive airway pressure is main treatment of OSA. lifestyle corrections also recommended

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 4, 2026

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

February 26, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 3, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 20, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 20, 2026

Completed
Last Updated

March 3, 2026

Status Verified

February 1, 2026

Enrollment Period

6 months

First QC Date

February 26, 2026

Last Update Submit

February 26, 2026

Conditions

Primary Open Angle GlaucomaObstructive Sleep ApneaObesity

Outcome Measures

Primary Outcomes (1)

  • Intraocular pressure

    it will be measured by tonometery

    it will be measured after 12 weeks

Secondary Outcomes (6)

  • apnea hypopnea index

    It will be measured after 12 weeks

  • Epowrth sleepiness scale

    It will be measured after 12 weeks

  • body mass index

    It will be measured after 12 weeks

  • waist circumference

    it will be measured after 12 weeks

  • neck circumferfence

    It will be measured after 12 weeks

  • +1 more secondary outcomes

Study Arms (2)

group number 1

EXPERIMENTAL

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group I will apply CPAP during night sleeping daily for three month. group I will apply lifestyle corrections (low calories diet intake and 3-session per-week 40-minute treadmill walking for three month.

Behavioral: lifetyle corrections and CPAP

group number 2

ACTIVE COMPARATOR

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group II will apply CPAP during night sleeping daily for three month.

Other: CPAP

Interventions

lifetyle corrections and CPAPBEHAVIORAL

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group I will apply CPAP during night sleeping daily for three month. group I will apply lifestyle corrections (low calories diet intake and 3-session per-week 40-minute treadmill walking for three month.

group number 1
CPAPOTHER

twenty glaucoma patients (high tension priamry open angle form) with OSA, intraocular pressure more than 21 mmHg, and obesity will be involved in group II will apply CPAP during night sleeping daily for three month.

group number 2

Eligibility Criteria

Age30 Years - 50 Years
Sexall(Gender-based eligibility)
Gender Eligibility Detailsbased on self-representation of gender identity.
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Obstructive sleep apnea patients
  • obese patients
  • glaucoma (open angle form with ocular hyoertension)

You may not qualify if:

  • cardiac patients renal patients hepatic patients

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cairo University

Giza, Dokki, Egypt

RECRUITING

MeSH Terms

Conditions

Glaucoma, Open-AngleSleep Apnea, ObstructiveObesity

Condition Hierarchy (Ancestors)

GlaucomaOcular HypertensionEye DiseasesSleep Apnea SyndromesApneaRespiration DisordersRespiratory Tract DiseasesSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesOverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Ali MA Ismail, lecturer

    Cairo University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ali MA Ismail, lecturer

CONTACT

01005154209ali.mohamed@pt.cu.edu.eg

ali mohamed, lecturer

CONTACT

0201031321109fatmaraed1994@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
lecturer of physical therapy for Cardiovascular, Respiratory disorder and Geriatrics, Faculty of Physical Therapy, Cairo University

Study Record Dates

First Submitted

February 26, 2026

First Posted

March 3, 2026

Study Start

February 4, 2026

Primary Completion

July 20, 2026

Study Completion

July 20, 2026

Last Updated

March 3, 2026

Record last verified: 2026-02

Locations

EG(1)