Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material

NCT07445776 | Completed

• 1 other identifier: A0303024OS
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University

Conditions

Immediate Implant Placement; Gap Filling With e-PRF; Gap Filling With Allograft

Outcome Measures

Primary Outcomes (1)

• Implant stability

  Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by (Osstell Mentor Device)

  immediately ,6months follow up & one year

Secondary Outcomes (1)

• Marginal bone loss

  immeditely,6months follow up & one year

Study Arms (2)

Group 1

EXPERIMENTAL

14 immediate implants placed in the maxillary esthetic zone then placement of allograft in the gap distance around the implant.

Other: Allograft

Group 2

EXPERIMENTAL

14 immediate implants placed in the maxillary esthetic zone then placement of e-PRF in the gap distance around the implant.

Other: e-PRF

Interventions

Allograft OTHER

after immediate implant placement the gap will be filled with allograft

Group 1

e-PRF OTHER

after immediate implant placement the gap will be filled with e-PRF

Group 2

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with badly destructed teeth due to trauma or caries.
• Patients willing to complete the study follow up intervals.
• Patients with good oral hygiene.
• Adequate inter-arch space that can accommodate implant abutment and future restoration.
• No gender preference in selection of the patients.

You may not qualify if:

• Patients with systemic diseases that absolutely contraindicate dental implant placement.
• Patients with parafunctional habits (bruxism and clenching).
• Heavy smokers (i.e. More than 20 cigarettes/day)34 and alcoholism.
• Presence of local infection or lesions at the proposed area for dental implant.
• Pregnancy.
• Patient taking drugs that could affect bone healing process as immunosuppressive drugs and bisphosphonates.
• Patients with bad oral hygiene and untreated periodontal disease
• Uncooperative patients

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Faculty of Dentistry, Mansoura University

Al Mansurah, 002, Egypt

Location

MeSH Terms

Interventions

Transplantation, Homologous

Intervention Hierarchy (Ancestors)

Transplantation; Surgical Procedures, Operative

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching assistant of oral and maxillofacial surgery

Study Record Dates

• First Submitted: February 25, 2026
• First Posted: March 3, 2026
• Study Start: May 1, 2024
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2025
• Last Updated: March 3, 2026

Record last verified: 2026-02

Locations

EG (1)