Effect of Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant
Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.
1 other identifier
interventional
20
1 country
1
Brief Summary
The objective of this study will be to compare between Immediate Implant grafted with xenograft and Alb-PRF gel versus xenograft with L-PRF.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 27, 2025
CompletedFirst Posted
Study publicly available on registry
March 7, 2025
CompletedStudy Start
First participant enrolled
August 20, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 10, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
February 10, 2027
ExpectedAugust 1, 2025
July 1, 2025
6 months
February 27, 2025
July 30, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Vertical peri-implant bone level
the distance between implant platform to the most coronal bone-implant contact
Immediate Post-Operative and 6 months after surgery
Keratinized tissue Width
Width of Keratinized tissue before and after surgery
Immediate Post-Operative and 6 months after surgery
Crestal bone level
distance between implant platform and bone crest
Immediate Post-Operative and 6 months after surgery
Secondary Outcomes (2)
Implant Stability
Immediate Post-Operative and 6 months after surgery
Bucco-lingual bone width
Immediate Post-Operative and 6 months after surgery
Study Arms (2)
Albumin-PRF group
EXPERIMENTALImmediate Implant Placement in lower molar region, Grafted with Xenograft and Albumin PRF Gel
L-PRF group
EXPERIMENTALImmediate Implant Placement in lower molar region, Grafted with Xenograft and L-PRF ( L-PRF Block )
Interventions
Immediate Implant Placement in lower molar region, Grafted with Xenograft and Albumin PRF Gel
Immediate Implant Placement in lower molar region, Grafted with Xenograft and L-PRF
Eligibility Criteria
You may qualify if:
- The presence of non-restorable mandibular molar.
- Patient 18-45 years old
- Intact buccal and lingual walls
- Good oral hygiene.
- Prescence of sufficient restorative space.
- Jumping gap more than 2 mm.
You may not qualify if:
- Proximity of anatomical structures
- Acute localized infection (suppuration at the surgical field)
- Patients on chemotherapy or radiotherapy.
- Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},
- Pregnant patients.
- Smoking and Alcohols.
- Presence of periapical pathology affecting the neighboring teeth.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kafrelsheikh University, Faculty of Dentistry
Kafr ash Shaykh, Kafrelsheikh, Egypt
Central Study Contacts
Mostafa Mohamed Fayed, Demonstrator of Periodontology
CONTACT
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Demonstrator of Periodontology
Study Record Dates
First Submitted
February 27, 2025
First Posted
March 7, 2025
Study Start
August 20, 2025
Primary Completion
February 10, 2026
Study Completion (Estimated)
February 10, 2027
Last Updated
August 1, 2025
Record last verified: 2025-07