10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology

NCT07443566 | Completed

• 1 other identifier: HOFTDEM_10 years
• Study Type: observational
• Target: 404
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.

Conditions

Hip Fractures (ICD-10 72.01-72.2); Alzheimer s Disease; Dementia

Outcome Measures

Primary Outcomes (1)

• All-cause mortality / survival at 10 years after index hip fracture surgery

  up to 10 years post-surgery

Secondary Outcomes (2)

• Time to death from date of surgery (survival time)

  10 years ( up to 10 years post-surgery)

• Association between baseline CDR category and long-term mortality

  up to 10 years

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adults (≥65 years) who were admitted for acute hip fracture and underwent surgical repair under spinal anesthesia at Sahlgrenska University Hospital, Mölndal, Sweden. Participants were originally enrolled between October 2013 and June 2015 and had pre-fracture cognitive status assessed using the Clinical Dementia Rating scale and cerebrospinal fluid biomarkers related to Alzheimer's disease collected at baseline. The present study is a long-term follow-up of this cohort.

You may qualify if:

• Participant enrolled in the original acute hip fracture cohort (index surgery during Oct 2013-Jun 2015 at Sahlgrenska University Hospital, Mölndal)
• Available personal identity number enabling linkage to Swedish registries
• Baseline cognitive assessment (CDR) and/or CSF biomarker data available from the index admission

You may not qualify if:

• Missing linkage information preventing ascertainment of vital status

Sponsors & Collaborators

• Bengt Nellgård: lead

Study Sites (1)

Sahlgrenska University Hospit

Mölndal, Västra Götaland County, 431 80, Sweden

Location

MeSH Terms

Conditions

Hip Fractures; Dementia

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 25, 2026
• First Posted: March 2, 2026
• Study Start: October 1, 2013
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: March 2, 2026

Record last verified: 2026-02

Locations

SE (1)