Frailty and Outcomes in Older Emergency Department Patients With Pneumonia

NCT07442656 | Recruiting

• 1 other identifier: 26-1.1T/96
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on acute physiological derangements and may not adequately capture biological reserve and frailty in older adults. Frailty is a geriatric syndrome reflecting increased vulnerability to stressors and reduced recovery capacity. This prospective observational cohort study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS) for in-hospital mortality, 30-day mortality, and morbidity in patients aged 65 years and older presenting to the emergency department with pneumonia. Additionally, the study will assess whether incorporating frailty assessment into existing pneumonia severity scores improves prognostic accuracy.

Conditions

Community-Acquired Pneumonia; Fraility; Hospitalizations

Keywords

Fraility; Clinical Fraility Scale; Older adults; Geriatric Emergency Medicine

Outcome Measures

Primary Outcomes (1)

• In hospital mortality

  All-cause mortality occurring during the same hospital admission after emergency department presentation.

  During index hospitalization (7 and 14 days)

Interventions

Clinical frailty scale OTHER

Frailty assessment performed at emergency department presentation using the 9-point Clinical Frailty Scale.

Clinical Frailty Scale (CFS) DIAGNOSTIC_TEST

The Clinical Frailty Scale (CFS) will be assessed on a 1-9 scale. The CFS score obtained at presentation will also be compared with the patient's baseline CFS prior to the onset of the current illness symptoms.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adults aged 65 years and above presenting to a tertiary university hospital emergency department with a clinical and radiological diagnosis of pneumonia. The study population represents geriatric patients with acute infectious respiratory illness requiring emergency evaluation, including a wide range of comorbidity and functional status levels typical of real-world emergency department practice.

You may qualify if:

• Age ≥65 years
• Clinical and radiological diagnosis of pneumonia in the emergency department
• Ability to obtain informed consent from the patient or legal representative
• Availability of a caregiver or relative able to describe baseline functional status

You may not qualify if:

• Presentation with cardiopulmonary arrest or ongoing cardiopulmonary resuscitation at admission
• Confirmed COVID-19 pneumonia
• Inability to obtain reliable baseline functional history due to absence of an informant
• Refusal to provide informed consent

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Özge Can

Izmir, Bornova, 35100, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Community-Acquired Pneumonia

Condition Hierarchy (Ancestors)

Community-Acquired Infections; Infections; Pneumonia; Respiratory Tract Infections; Respiratory Tract Diseases

Central Study Contacts

Özlem İnci, MD

CONTACT

902323902321; ozge.can@ege.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Emergency physician

Study Record Dates

• First Submitted: February 14, 2026
• First Posted: March 2, 2026
• Study Start: January 1, 2026
• Primary Completion: March 30, 2026
• Study Completion: April 30, 2026
• Last Updated: March 2, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)