The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients

NCT07442370 | Recruiting

• 1 other identifier: Uskudar91
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to contribute to clinical applications by investigating the effectiveness of functional rotation exercises on fall risk, mobility, and balance in patients diagnosed with idiopathic Parkinson's disease.

Conditions

Parkinson Disease; Parkinsonism

Outcome Measures

Primary Outcomes (2)

• Timed Up and Go Test

  This outcome measure will be used to assess functional mobility using a virtual reality-based adaptation of the Timed Up and Go test. Test completion time will be automatically recorded by the system. Validity and reliability will be examined through comparison with the conventional Timed Up and Go test and repeated measurements.

  10 weeks

• Berg Balance Test

  Berg Balance Test is consisting of 14 items and measures the ability of individuals to maintain balance while performing functional tasks. Each task is scored from 0 (cannot perform independently) to 4 (stated best performance). 0-20 points are interpreted as high risk of falling, between 21-40 points as medium risk of falling, and between 41-56 points as low risk.

  10 weeks

Study Arms (2)

control group

ACTIVE COMPARATOR

only patients who will receive a conventional physiotherapy program

Other: conventional physiotherapy

exercise group

EXPERIMENTAL

Patients who will receive a special exercise program in addition to a conventional physiotherapy program.

Other: conventional physiotherapy; Other: conventional physiotherapy + exercise

Interventions

conventional physiotherapy OTHER

Conventional physiotherapy will be applied for 6 weeks, with 3 sessions per week, each session lasting approximately 40-50 minutes. Participants will be given stretching and flexibility exercises (trunk, shoulder and lower extremity muscle groups) in each session, with 10 repetitions x 15 seconds. Balance exercises (3 repetitions for 30-45 seconds in static and dynamic balance positions), walking exercises on a flat surface, and strengthening exercises (2-3 sets, 10-12 repetitions with resistance band or dumbbells) will be performed.

control group; exercise group

conventional physiotherapy + exercise OTHER

This group will receive conventional physical therapy and functional rotation exercises for 6 weeks, with 3 sessions per week, each session lasting approximately 40-50 minutes.

exercise group

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals with a clinical diagnosis of idiopathic Parkinson's disease (Hoehn \& Yahr stages 1-2)
• Individuals aged 50-70 years
• Mini Mental State Test score ≥ 24
• Individuals whose medical treatment has been stable in the last 6 weeks
• Individuals with stable vital signs
• Individuals who volunteer to participate in the study and understand the purpose and process of the study, and who have signed a written informed consent form

You may not qualify if:

• Advanced Parkinson's disease (H\&Y 3-5)
• Severe orthopedic problems
• Vestibular system disorders
• History of serious falls in the last 6 months

Sponsors & Collaborators

• Uskudar University: lead

Study Sites (1)

Sancak Medical Center

Istanbul, Sancaktepe, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Bellows S. Physiotherapy and Exercise in Parkinson's Disease. Neurol Clin. 2025 May;43(2):427-443. doi: 10.1016/j.ncl.2024.12.014. Epub 2025 Jan 24.

  PMID: 40185529 BACKGROUND

• Zhang J, Wu M, Hou X, Song W, Li J, Teng L, Li X, Yu D, Pan J, Zhu L. Unconventional exercises for motor function in Parkinson's disease: an umbrella review of meta-analyses. Age Ageing. 2025 Mar 3;54(3):afaf062. doi: 10.1093/ageing/afaf062.

  PMID: 40125629 BACKGROUND

• Jansen JA, Buurke TJ, van de Venis L, Weerdesteyn V, Keijsers N, Nonnekes J. Narrow-based gait in people with Parkinson's disease: Its mechanisms explored. J Parkinsons Dis. 2025 Mar;15(2):329-337. doi: 10.1177/1877718X241313333. Epub 2025 Feb 2.

  PMID: 39973508 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease; Parkinsonian Disorders

Interventions

Exercise

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Kübra UZUN

  Uskudar University

  STUDY CHAIR

Central Study Contacts

Ömer ŞEVGİN

CONTACT

+905069787535; omer.sevgin@uskudar.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc.Prof.Dr.

Study Record Dates

• First Submitted: February 25, 2026
• First Posted: March 2, 2026
• Study Start: March 1, 2026
• Primary Completion: July 15, 2026
• Study Completion (Estimated): September 15, 2026
• Last Updated: March 3, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)