NCT07441785|Recruiting
Immediate and Functional Results of Different Types of Reconstructions After Proximal Gastrectomy For Gastric and Esophagogastric Junction Cancer
PROXISTAT
Loading search results
PROXISTAT
Sponsor study identifier
observational
400
1 country
1
Study Start
January 1, 2025
Actual (reported)Primary Completion
December 31, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Proximal gastric and esophagogastric junction cancers comprise up to 40% of gastric malignancies. For localized disease, proximal gastrectomy is the main radical procedure, but reconstruction of GI tract often leads to significant functional issues. Rising use of proximal resections and broader indications have increased attention to postoperative quality of life (QoL). Common reconstructions include direct esophagogastrostomy (various types), double-tract reconstruction, jejunal interposition, and newer anti-reflux anastomoses (e.g., double-flap, overlap, tunnel techniques). Each method has unique pros and cons regarding reflux esophagitis, food passage, dumping syndrome, nutritional changes, and long-term QoL. No consensus exists on the optimal technique, leading to variable practices and outcomes. Most research focuses on oncologic radicality and survival, while functional results and QoL remain understudied. Systematic evaluation of functional outcomes across reconstruction types after proximal subtotal gastrectomy is needed in Russian Federation to improve QoL, advance research, and standardize treatment of proximal gastric and EGJ cancers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2025
Actual (reported)February 24, 2026
Actual (reported)March 2, 2026
Actual (reported)December 31, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The structure and frequency of postoperative complications depending on the method of reconstruction, as well as neoadjuvant treatment
the types of complication is classified into as follows: esophageal anastomotic leak requiring surgical treatment, esophageal anastomotic leak not requiring surgical treatment, gastric stump necrosis, postoperative bleeding requiring surgical treatment, postoperative bleeding not requiring surgical treatment, postoperative ileum, postoperative pancreatic fistula type B, postoperative pancreatic fistula type C, duodenal stump leak / duodenal stump insufficiency, impaired evacuation from the gastric stump (more than 10 days after surgery), postoperative intestinal perforation or necrosis, persistent air leak through the pleural drain, wound dehiscence (evisceration, hernia), incarcerated diaphragmatic hernia, chylothorax or other types of lymph leakage, infectious complications of the postoperative wound, other complications requiring repeat intervention or another invasive procedure, other.
within 90 days after operation
Overall survival
Overall survival within 1 year after operation
1 year after operation
Patients who suffered from any type of morbidity after surgery
Patients who did not suffered from any type of morbidity after surgery
Resection of the upper third to one-half of the stomach and the distal portion of the esophagus with different types of digestive system reconstruction
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
All consecutive patients with clinically documented primary Gastric or Esophagogastric Junction malignancy (including Siewert II and III) cT1-3N0-2M0undergoing elective proximal gastrectomy curative intent - via open, laparoscopic or robotic approach
P.Herzen Moscow Oncological Research Institute
Moscow, Russia
Andrey Ryabov, MD, PhD
P.Herzen Moscow Oncological Research Institute
Vladimir Khomyakov, MD, PhD
P.Herzen Moscow Oncological Research Institute
Nuriddin Abdulkhakimov, PhD
P.Herzen Moscow Oncological Research Institute
Pavel Smirnov
P.Herzen Moscow Oncological Research Institute
First Submitted
February 24, 2026
First Posted
March 2, 2026
Study Start
January 1, 2025
Actual (reported)Primary Completion
December 31, 2028
EstimatedFrequency of local recurrence
Frequency of local recurrence within 1 year after operation
1 year after operation
Frequency of tumor progression
Frequency of tumor progression within 1 year after operation
1 year after operation
Incidence of development and the severity of reflux esophagitis
6 and 12 months after surgery
Incidence of development of esophageal anastomotic stricture
6 and 12 months after surgery
Incidence and severity of dumping syndrome
6 and 12 months after surgery
Pressure of the esophageal anastomosis
6 and 12 months after surgery
The level of body weight reduction
6 and 12 months after surgery
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 1, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 22, 2026
Record last verified: 2026-04
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: