PG Versus TG for Advanced PGC

NCT06614439 | Completed

• 1 other identifier: 202408135RIND
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

We conducted a retrospective study on patients with pathological stage II-III PGC who underwent PG or TG from 2013 to 2023. Propensity score-matching was applied to adjust for tumor size and stage between the PG and TG groups at a 1:1 ratio. We evaluated the procedural safety, oncological, and functional outcomes.

Conditions

Gastric Adenocarcinoma; Gastrectomy

Outcome Measures

Primary Outcomes (1)

• five-year overall survival

  5 years

Study Arms (2)

Proximal gastrectomy

EXPERIMENTAL

Procedure: proximal gastrectomy

Total gastrectomy

ACTIVE COMPARATOR

Procedure: total gastrectomy

Interventions

proximal gastrectomy PROCEDURE

proximal gastrectomy

Proximal gastrectomy

total gastrectomy PROCEDURE

total gastrectomy

Total gastrectomy

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Proximal gastric adenocarcinoma after total or proximal gastrectomy.

You may not qualify if:

• Non-curative resections
• Non-adenocarcinoma histology
• Distally located tumors or middle/proximally located tumors for which distal margin could not be secured by PG
• Remnant gastric cancer
• Clinically T1N0 tumors smaller than 3 cm for which PG was clearly indicated

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital Hsin-Chu Branch

Hsin-Chu County, 302, Taiwan

Location

Related Publications (5)

• Lee S, Chae YS, Yun WG, Kim JC, Park JK, Kim MG, Kim J, Cho YS, Kong SH, Park DJ, Lee HJ, Yang HK. Long-Term Outcome of Proximal Gastrectomy for Upper-Third Advanced Gastric and Siewert Type II Esophagogastric Junction Cancer Compared With Total Gastrectomy: A Propensity Score-Matched Analysis. Ann Surg Oncol. 2024 May;31(5):3024-3030. doi: 10.1245/s10434-024-15048-8. Epub 2024 Feb 19.

  PMID: 38372863 BACKGROUND

• Peng R, Yue C, Wei W, Zhou B, Wen X, Gu RM, Ming XZ, Li G, Chen HQ, Xu ZK. Proximal gastrectomy may be a reasonable choice for patients with selected proximal advanced gastric cancer: A propensity score-matched analysis. Asian J Surg. 2022 Oct;45(10):1823-1831. doi: 10.1016/j.asjsur.2021.09.029. Epub 2021 Oct 9.

  PMID: 34642056 BACKGROUND

• Rosa F, Quero G, Fiorillo C, Bissolati M, Cipollari C, Rausei S, Chiari D, Ruspi L, de Manzoni G, Costamagna G, Doglietto GB, Alfieri S. Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer-GIRCG). Gastric Cancer. 2018 Sep;21(5):845-852. doi: 10.1007/s10120-018-0804-3. Epub 2018 Feb 8.

  PMID: 29423892 BACKGROUND

• Sugoor P, Shah S, Dusane R, Desouza A, Goel M, Shrikhande SV. Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary. Langenbecks Arch Surg. 2016 Aug;401(5):687-97. doi: 10.1007/s00423-016-1422-3. Epub 2016 May 4.

  PMID: 27143021 BACKGROUND

• Lee S, Son WJ, Roh YH, Song JH, Park SH, Cho M, Kim YM, Hyung WJ, Kim HI. Indication of Proximal Gastrectomy for Advanced Proximal Gastric Cancer Based on Lymph Node Metastasis at the Distal Part of the Stomach. Ann Surg Open. 2021 Nov 24;2(4):e107. doi: 10.1097/AS9.0000000000000107. eCollection 2021 Dec.

  PMID: 37637877 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 23, 2024
• First Posted: September 26, 2024
• Study Start: September 4, 2024
• Primary Completion: August 1, 2025
• Study Completion: September 1, 2025
• Last Updated: November 18, 2025

Record last verified: 2024-09

Locations

TW (1)