Study of Risk Factors and Prediction of Blood Clots After Lung Cancer Surgery

NCT07439991 | Recruiting

• 1 other identifier: JLUThorSurg-VTE02
• Study Type: observational
• Target: 900
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the risk factors and prediction of postoperative venous thromboembolism (VTE) in patients undergoing lung cancer surgery. The main question it aims to answer is: Which clinical, surgical, and laboratory factors are associated with the development of postoperative deep vein thrombosis (DVT) in lung cancer surgery patients, and can machine learning models accurately predict individual risk? Participants undergoing lung cancer surgery will be prospectively followed for 30 days after surgery. Perioperative clinical data, laboratory results, and imaging findings will be collected to identify VTE risk factors and to develop a predictive model.

Conditions

Lung Cancer (Diagnosis); Deep Vein Thrombosis (DVT); Venous Thromboembolism (VTE)

Outcome Measures

Primary Outcomes (1)

• Incidence of postoperative deep vein thrombosis (DVT) in lung cancer surgery patients

  The primary outcome is the occurrence of postoperative deep vein thrombosis (DVT) within 30 days after lung cancer surgery, confirmed by Doppler ultrasound of the lower extremities. Perioperative clinical, laboratory, and imaging variables will be collected prospectively and analyzed to identify risk factors and develop machine learning-based predictive models for individual DVT risk.

  From the day of lung cancer surgery to 30 days postoperatively

Secondary Outcomes (1)

• Identification of perioperative risk factors for postoperative deep vein thrombosis (DVT) in lung cancer surgery patients

  From the day of surgery to 30 days postoperatively

Study Arms (2)

VTE Group

Adult patients undergoing lung cancer surgery who develop postoperative deep vein thrombosis (DVT) within 30 days. Perioperative clinical, laboratory, and imaging data will be collected to identify risk factors and build predictive models.

Other: Prospective Perioperative Data Collection

Non-VTE Group

Adult patients undergoing lung cancer surgery who do not develop postoperative DVT within 30 days. Perioperative clinical, laboratory, and imaging data will be collected for comparison with the VTE group.

Other: Prospective Perioperative Data Collection

Interventions

Prospective Perioperative Data Collection OTHER

The intervention involves the prospective collection of perioperative clinical, laboratory, and imaging data from adult patients undergoing lung cancer surgery. No therapeutic or diagnostic procedures beyond standard care are applied. Collected data will be used to identify risk factors for postoperative deep vein thrombosis (DVT) and to develop machine learning-based predictive models.

Non-VTE Group; VTE Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients undergoing surgical resection for lung cancer at the Department of Thoracic Surgery, First Hospital of Jilin University. Participants will be prospectively followed for 30 days postoperatively to assess the occurrence of deep vein thrombosis (DVT) and to identify perioperative risk factors. All patients meeting inclusion criteria and without exclusion criteria will be eligible.

You may qualify if:

• Age ≥ 18 years
• Patients undergoing surgical resection for lung cancer
• Postoperative hospital stay ≥ 48 hours
• Availability of perioperative clinical, laboratory, and imaging data
• Willingness to provide informed consent and participate in 30-day follow-up

You may not qualify if:

• Pre-existing deep vein thrombosis (DVT) or pulmonary embolism (PE) before surgery
• Preoperative or ongoing anticoagulation therapy for ≥ 2 weeks
• Severe coagulation disorders or bleeding diseases
• Severe hepatic, renal, or hematologic dysfunction, or uncontrolled systemic infection
• Concurrent major organ surgery (e.g., cardiac, liver surgery)
• Pregnancy or lactation
• Incomplete postoperative follow-up data

Sponsors & Collaborators

• The First Hospital of Jilin University: lead

Study Sites (1)

The First Hospital of Jilin University, Department of Thoracic Surgery

Changchun, Jilin, 130021, China

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms; Disease; Venous Thrombosis; Venous Thromboembolism

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Thrombosis; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Thromboembolism

Central Study Contacts

Wei Liu

CONTACT

86-13596083366; l_w01@jlu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 23, 2026
• First Posted: February 27, 2026
• Study Start: November 1, 2024
• Primary Completion (Estimated): November 1, 2029
• Study Completion (Estimated): November 30, 2029
• Last Updated: February 27, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)