Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills

NCT07437807 | Completed

• 1 other identifier: 56664061-050.01.04-E.2309
• Study Type: observational
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. In addition to testing the hypothesis that rehabilitation protocols targeting amblyopia related visual-perceptual and visual-cognitive skills. Spesific aims of this study are:

1. 1.to identify which visual perceptual skills are most significantly impaired sen patients with amblyopia.
2. 2.to evaluate whether interventions are targeting fundamental visual perceptual skills are associated with improvements in higher-order visual perceptual skills.
3. 3.to determine whether vision therapy tailored to individual neuro-visual impairments associated with improvements in binocular function, including streopsis and overall visual perceptual performance.
4. 4.to ases whether baseline neuro-visual perceptual performance predicts the response to vision therapy in patients with amblyopia.

Conditions

Amblyopia

Keywords

Amblyopia; Vision Therapy; Visual Perceptual Skills; Visual-Cognitive Skills; Neuroplasticity

Outcome Measures

Primary Outcomes (1)

• The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills

  From June 2024 to June 2025

Study Arms (1)

Amblyopia patients enrolled in vision therapy

Amblyopia patients who are unresponsive to treatmens ( occlusion therapy, atropinization, strabismus surgery) and enrolled in vision therapy

Diagnostic Test: Motor Free Perception Vision Test

Interventions

Motor Free Perception Vision Test DIAGNOSTIC_TEST

The Motor-Free Visual Perception Test-3 (MVPT-3) represents a significant methodological iteration in the assessment of non-motor visual processing, specifically validated for individuals ranging from 4 to 95 years of age. In pediatric and adolescent contexts (under 18), the MVPT-3 is utilized to isolate cognitive visual-perceptual skills-such as spatial relationships, visual discrimination, figure-ground, and visual closure-from fine motor coordination, which may still be developing or impaired. The test consists of 65 items arranged in a horizontal format to accommodate individuals with hemispatial neglect or limited field of vision. For younger examinees, the assessment is particularly vital for identifying perceptual deficits that may impede academic performance, such as reading fluency or mathematical reasoning, without the results being skewed by the child's handwriting or drawing abilities. By providing age-adjusted normative data, the MVPT-3 allows clinicians to derive standard

Amblyopia patients enrolled in vision therapy

Eligibility Criteria

• Age: 4 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

38 amblyopia patients who are admitted to the Dr.Semrin Timlioğlu İper Clinic and Okan University. During the time period: June 2024-June 2025. Patients are unresponsive to traditional treatments such as: strabismus surgery, occlusion therapy and atropinization. They recieved personalized vision therapy programme based on their visual-cognitive and perceptual skills.

You may qualify if:

• Ambylopia patient
• Minimal response to traditional treatments
• Ages between 4-18
• Receiving personalized vision therapy
• Taking the TVPS-3 at least 2 times

You may not qualify if:

• Responsive to treatment
• Discontinued vision therapy

Sponsors & Collaborators

• Okan University: lead

Study Sites (1)

Okan University

Istanbul, Turkey (Türkiye)

Location

Related Links

• Comparison between binocular therapy and patching for treatment of amblyopia: a meta-analysis of randomised controlled trials
• Comparison of a novel gamified binocular therapy and standard monocular patching therapy in treating unilateral amblyopia in young children: a prospective, multicenter, randomized controlled trial
• Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years
• New advances in amblyopia therapy I: binocular therapies and pharmacologic augmentation
• Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system
• Effect of vision-based treatments on visual acuity and motor function in children with amblyopia
• Enhanced Gray Matter Volume Compensates for Decreased Brain Activity in the Ocular Motor Area in Children with Anisometropic Amblyopia
• The Impact of Binocular Vision and Tracking Intervention on Academic Performance: An In-School Vision Therapy Pilot Program
• Recent understanding of binocular vision in the natural environment with clinical implications
• Layer 4 Gates Plasticity in Visual Cortex Independent of a Canonical Microcircuit
• Time Course and Predictors of Amblyopia Improvement with 2 Hours of Daily Patching
• A randomized trial comparing Bangerter filters and patching for the treatment of moderate amblyopia in children
• Deficits in perception of images of real-world scenes in patients with a history of amblyopia
• Patient-reported outcome measures in amblyopia and strabismus: a systematic review
• Vision therapy improves binocular visual dysfunction in patients with mild traumatic brain injury
• The functional impact of amblyopia
• Fine Motor Skills of Children With Amblyopia Improve Following Binocular Treatment
• A Low Vision Student at a Younger School Age in Public School. A Case Study

MeSH Terms

Conditions

Amblyopia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor H.Semrin Timlioğlu İper

Study Record Dates

• First Submitted: February 23, 2026
• First Posted: February 27, 2026
• Study Start: June 12, 2024
• Primary Completion: June 12, 2025
• Study Completion: September 30, 2025
• Last Updated: March 10, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF, CSR, ANALYTIC CODE
• Access Criteria: Open access for academics

Locations

TU (1)