A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Study to Assess the Efficacy and Safety of XW003 Injections in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
Sponsor study identifier
interventional
140
1 country
1
Study Start
March 2, 2026
Actual (reported)Primary Completion
June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA receiving PAP
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 28, 2026
Actual (reported)February 25, 2026
Actual (reported)March 2, 2026
Actual (reported)June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change from baseline in Apnea-Hypopnea Index (AHI)
at week 48
Percent Change From Baseline in AHI
at week 48
Percentage of Participants With ≥50% AHI Reduction From Baseline
at week 48
Percentage of Participants With AHI <5 or With AHI 5-14 With Epworth Sleepiness Scale (ESS) ≤10
at week 48
Percent Change From Baseline in body weight
at week 48
once weekly
once weekly
subcutaneous injection
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Rui Jin Hospital
Shanghai, Shanghai Municipality, 200025, China
Qingyun Li, Dr
Ruijin Hospital
First Submitted
January 28, 2026
First Posted
February 25, 2026
Study Start
March 2, 2026
Actual (reported)Primary Completion
June 19, 2028
EstimatedContact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 19, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 28, 2026
Record last verified: 2026-01
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Source: ClinicalTrials.gov.
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