Antimicrobial Photodynamic Therapy Or Lingual Scraper Associated With Periodontal Treatment In The Reduction Of Halitosis.

NCT07433816 | Completed

• 1 other identifier: BNW/NWN/0052/KB1/77/24
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare the effectiveness of two methods of treating bad breath. Patients are enrolled in the study based on an objective test using the Oral Chroma Device, which measures the concentration of volatile sulfur compounds in exhaled air, which are responsible for bad breath. Before the test begins, a sample will also be taken from the tongue to determine the total number of microorganisms. Patients are then randomly assigned to two groups. Control group: Cleaning the tongue with a tongue scraper and rinsing the mouth with an antiseptic mouthwash. Intervention group: Cleaning the tongue with a tongue scraper and antibacterial laser therapy on the tongue. Then, all study participants will undergo a procedure to clean tartar from all their teeth. Questions to be answered by the study: Will there be a decrease in the concentration of volatile sulfur compounds in exhaled air after treatment? Will the treatment results obtained after laser therapy be better compared to the classic method of treating bad breath? Cleaning procedures within the tongue will be performed at the beginning, then repeated after one week, two weeks, and 3 months from the baseline. After each stage, the concentration of substances in exhaled air that are responsible for bad breath will be measured. Samples will be taken from the tongue to determine the total number of microorganisms before the first tongue cleaning, and then after 2 weeks from the intervention.

Conditions

Halitosis; Halitoses; Fetor Oris; Oral Malodor

Outcome Measures

Primary Outcomes (2)

• Total number of microorganisms

  Swab samples were collected from the dorsum of the tongue (posterior third). The material collected from the tongue was inoculated separately onto the Rodac ConTact Test to determine the total number of microorganisms.

  At the baseline, 2 weeks after the baseline

• Values of concentration of VSCs (volatile sulfur compounds) in exhaled air

  Values of concentration of VSCs above 112 ppb (1.5 ng/10 mL) were indicators of halitosis.

  at the baseline, one week after the baseline, two weeks after the baseline,3 months after the baseline

Study Arms (2)

Photodynamic therapy

EXPERIMENTAL

Procedure: Tongue scraper and aPDT (photodynamic therapy); Procedure: full mouth scaling

Rinsing the mouth

EXPERIMENTAL

Procedure: Tongue scraper and oral rinse treatment; Procedure: full mouth scaling

Interventions

Tongue scraper and oral rinse treatment PROCEDURE

The procedure involves treating the tongue with a tongue scraper and rinsing the mouth with a chlorhexidine solution.

Rinsing the mouth

Tongue scraper and aPDT (photodynamic therapy) PROCEDURE

The procedure involves treatment with a tongue scraper and photodynamic therapy with toluidine blue using a diode laser.

Photodynamic therapy

full mouth scaling PROCEDURE

removal of tartar deposits within both dental arches

Photodynamic therapy; Rinsing the mouth

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Participants diagnosed with halitosis based on an objective exhaled sulfhydryl (H2S) concentration of ≥ 112 ppb (1.5 ng/10 mL) determined by gas chromatography (Oral Chroma) and who signed an informed consent form previously approved by the Bioethics Committee were included in the study.

You may not qualify if:

• The study excluded patients with a history of the following diseases:
• otolaryngological, i.e., chronic tonsillitis (presence of tonsil plugs), chronic sinusitis, head and neck cancer
• gastrointestinal, i.e., Helicobacter Pylori infection, esophageal diverticulitis, pyloric sphincter insufficiency, severe gastroesophageal reflux disease
• pulmonary, i.e., bronchitis, bronchiectasis, lung cancer - metabolic, i.e., diabetes, uremia, chronic renal failure, and liver disease as well as individuals taking pharmacotherapies such as antihistamines, steroids, anticholinergics, antispasmodics, alcohol consumers, smokers, and those suffering from severe obesity.
• on antibiotic or antifungals treatment up to 1 month before the survey,
• pregnant Additinaly indyviduals with local abnormalities were excluded: using a removable device, implant and/or prosthesis, with carious lesions, during orthodontic and/or orthopedic treatment, with hypersensitivity to the photosensitizer to be used.

Sponsors & Collaborators

• Medical University of Silesia: lead

Study Sites (1)

Department of Periodontology and Oral Mucosa Diseases

Zabrze, Silesian Voivodeship, 41-800, Poland

Location

MeSH Terms

Conditions

Halitosis

Interventions

Photochemotherapy

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Combined Modality Therapy; Therapeutics; Drug Therapy; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Group 1 (control): cleaning the tongue with a tongue scraper and rinsing the mouth with an antiseptic mouthwash with chlorheksidine Group two (intervention): cleaning the tongue with a tongue scraper and aPDT (photodynamic therapy with toluidine blue) The intervention will be performed at the beginning, then repeated after 1 week, two weeks, and 3 months.

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: June 20, 2025
• Primary Completion: October 30, 2025
• Study Completion: December 30, 2025
• Last Updated: March 5, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)