Evaluation of Endothelial Dysfunction in Geriatric Non-dialysis Chronic Kidney Disease Patients

NCT07430982 | Completed DMC

• 1 other identifier: 23/159/02/3/4
• Study Type: interventional
• Target: 101
• Locations: 1 country
• Sites: 1

Brief Summary

Brief summary template The goal of this clinical trial is to assess endothelial dysfunction in geriatric non-dialysis CKD patients. The main questions it aims to answer are:

• In geriatric non-dialysis CKD patients, the study aimed to demonstrate the relationship between soluble vascular endothelial cadherin and fibroblast growth factor-23 levels, which are indicators of endothelial dysfunction-and therefore a possible cardiovascular risk factor-using measurement methods such as ultrasonographic carotid intima-media thickness, flow-mediated dilation, and nailfold capillaroscopy. Participants will have measurement of;
• ultrasonographic carotid intima-media thickness,
• flow-mediated dilation,
• nailfold capillaroscopy
• venous blood sampling
• Visit the clinic once,

Conditions

Geriatrics; Chronic Kidney Disease; Carotis Intima-media Thickness

Keywords

geriatrics; chronic kidney disease; soluble vascular endothelial cadherin; FGF-23

Outcome Measures

Primary Outcomes (2)

• Correlation of serum sVE cadherin level and other measurements

  To investigate the relationship between sVE cadherin levels and ultrasonographic carotid intima-media thickness (CIMT), flow-mediated dilation(FMD), nailfold capillaroscopy(NC) test results measured in patients.

  Approximately 122 days were sufficient for patient recruitment for the study. After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status.

• Distribution of sVE cadherin levels in the patient group

  sVE cadherin levels

  Approximately 122 days were sufficient for patient recruitment for the study. After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status.

Secondary Outcomes (1)

• All-cause mortality

  After patient recruitment was completed, we followed the patients for approximately 844 days, monitoring their survival/death status.

Study Arms (1)

STUDY GROUP

OTHER

THE ONLY GROUP IN THE STUDY.MEASUREMENT OF CIMT,FMD,NC.

Diagnostic Test: Ultrasonographic and Capillary Measurements

Interventions

Ultrasonographic and Capillary Measurements DIAGNOSTIC_TEST

All measurements will be applied to the entire patient group.

Also known as: measurement of flow-mediated dilation, measurement of nailfold capillaroscopy, measurement of ultrasonographic carotid intima-media thickness

STUDY GROUP

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Patients diagnosed with CKD who are not receiving RRT and those aged 65 and over

You may not qualify if:

• Patients under 65 years of age
• history of coronary artery disease
• history of peripheral artery disease
• atrial fibrillation
• heart failure
• active immunosuppressive use
• active infection
• history of active malignancy
• history of cerebrovascular event (ischemic/hemorrhagic)
• Raynaud's phenomenon
• renal transplant patients

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

Study Sites (1)

Mugla Sitki Kocman University

Muğla, Muğla, 48000, Turkey (Türkiye)

Location

Related Publications (3)

• Harki O, Bouyon S, Salle M, Arco-Hierves A, Lemarie E, Demory A, Chirica C, Vilgrain I, Pepin JL, Faury G, Briancon-Marjollet A. Inhibition of Vascular Endothelial Cadherin Cleavage Prevents Elastic Fiber Alterations and Atherosclerosis Induced by Intermittent Hypoxia in the Mouse Aorta. Int J Mol Sci. 2022 Jun 24;23(13):7012. doi: 10.3390/ijms23137012.

  PMID: 35806017 BACKGROUND

• Soeki T, Tamura Y, Shinohara H, Sakabe K, Onose Y, Fukuda N. Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis. Circ J. 2004 Jan;68(1):1-5. doi: 10.1253/circj.68.1.

  PMID: 14695457 BACKGROUND

• Chang F, Flavahan S, Flavahan NA. Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in ageing rat arteries. J Physiol. 2017 Aug 1;595(15):5143-5158. doi: 10.1113/JP274189. Epub 2017 Jun 30.

  PMID: 28561330 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Alper Alp, Assoc Prof,MD

  Muğla Sıtkı Koçman University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, MD

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: February 24, 2026
• Study Start: May 12, 2023
• Primary Completion: September 11, 2023
• Study Completion: February 1, 2026
• Last Updated: February 24, 2026

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)