NCT07430007

Brief Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term randomized controlled trial evidence with objective AF burden assessment and advanced cardiac imaging is limited. The MOVE-AF trial is a randomized controlled trial designed to evaluate whether a 12-month tailored exercise and dietary lifestyle intervention, compared with usual care, reduces atrial fibrillation burden and symptom severity and decreases cardiac and total body fat mass in overweight and obese adults with paroxysmal or persistent AF.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
158

participants targeted

Target at P75+ for not_applicable

Timeline
31mo left

Started Oct 2025

Longer than P75 for not_applicable

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress20%
Oct 2025Dec 2028

Study Start

First participant enrolled

October 30, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

January 21, 2026

Completed
1 month until next milestone

First Posted

Study publicly available on registry

February 24, 2026

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Last Updated

February 24, 2026

Status Verified

January 1, 2026

Enrollment Period

2.2 years

First QC Date

January 21, 2026

Last Update Submit

February 23, 2026

Conditions

Atrial Fibrillation (AF)Obesity & Overweight

Keywords

Exercise trainingDietary interventionLifestyle interventionCardiac fatnessCardiorespiratory fitnessContinuous rhythm monitoringPhotoplethysmographyBody composition analysisCardiac MRICost effectivenessBody compositionQuality of lifeAF burdenAF symptoms

Outcome Measures

Primary Outcomes (1)

  • Atrial Fibrillation Burden

    Total atrial fibrillation burden measured by continuous rhythm monitoring over the intervention period. Unit of Measure: Percentage of time in atrial fibrillation (%)

    12 months

Secondary Outcomes (13)

  • Cardiac Fat Mass

    12 months

  • AF Symptom Severity

    12 months

  • Body Fat Mass

    12 months

  • Six-Minute Walk Test (6MWT)

    12 months

  • AF-Related Quality of Life (AFEQT Overall Score)

    12 months

  • +8 more secondary outcomes

Other Outcomes (5)

  • Natriuretic Peptides

    12 months

  • Dietary assessment

    12 months

  • Physical Activity Level

    12 months

  • +2 more other outcomes

Study Arms (2)

12-Month Tailored Exercise and Dietary Lifestyle Intervention

EXPERIMENTAL

Participants receive standard clinical care for atrial fibrillation plus a 12-month tailored lifestyle program including individualized aerobic exercise, muscle strength training, and dietary counseling.

Behavioral: Tailored Exercise and Dietary Lifestyle Program

Usual Clinical Care

OTHER

Participants receive standard clinical care for atrial fibrillation without any structured exercise or dietary lifestyle intervention.

Other: Usual Clinical Care

Interventions

Tailored Exercise and Dietary Lifestyle ProgramBEHAVIORAL

A 12-month tailored lifestyle program combining individualized aerobic exercise, muscle strength training, and dietary counseling. The program includes home-based aerobic training 2-5 times per week, muscle strength training, group-based dietary intervention sessions, and motivational support. The intervention is added to standard clinical care for atrial fibrillation.

Also known as: 12-Month Tailored Exercise and Dietary Lifestyle Intervention
12-Month Tailored Exercise and Dietary Lifestyle Intervention
Usual Clinical CareOTHER

Participants receive standard clinical care for atrial fibrillation according to the guideline-based routine practice at participating hospitals. No structured exercise or dietary lifestyle intervention is provided.

Usual Clinical Care

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18-75 years
  • Body mass index (BMI) ≥27 kg/m²
  • Documented atrial fibrillation (paroxysmal or persistent)
  • Ability to participate in exercise training and follow study procedures
  • Access to a smartphone or device enabling rhythm monitoring
  • Provides written informed consent

You may not qualify if:

  • Permanent atrial fibrillation
  • Unstable angina pectoris or acute coronary syndrome within the past 3 months
  • Participation in other lifestyle or drug weight reduction trials
  • Significant left ventricular dysfunction (ejection fraction \<30%)
  • Severe valvular heart disease or planned cardiac surgery
  • Severe heart failure (NYHA class IV) or severe angina (CCS class IV)
  • Unstable coronary artery disease or recent myocardial infarction
  • Severe pulmonary disease limiting exercise capacity
  • Active malignancy
  • Autoimmune or systemic inflammatory diseases
  • Severe renal or hepatic failure
  • Memory disease or significant cognitive impairment
  • Unstable psychiatric condition
  • Recent joint or back surgery within the past 6 months
  • Continuing back or joint pain symptoms and inability to take part in individualized exercise training
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Hospital Nova of Central Finland

Jyväskylä, Central Finland, Finland

RECRUITING

University of Eastern Finland

Kuopio, Eastern Finland, Finland

NOT YET RECRUITING

Kuopio University Hospital

Kuopio, Northern Savonia, Finland

NOT YET RECRUITING

Tampere University Hospital

Tampere, Finland

NOT YET RECRUITING

Related Publications (1)

  • Alanko L, Laukkanen JA, Rottensteiner M, Rasmus S, Kuha T, Valtonen M, Kujala UM. Sports and exercise medicine clinic in public hospital settings: a real-life concept and experiences of the treatment of the first 1151 patients. Postgrad Med. 2023 Apr;135(3):283-289. doi: 10.1080/00325481.2022.2135894. Epub 2022 Oct 18.

    PMID: 36254719RESULT

Related Links

MeSH Terms

Conditions

Atrial FibrillationObesityOverweight

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and Symptoms

Study Officials

  • Jari Laukkanen, MD, PhD

    University of Eastern Finland

    PRINCIPAL INVESTIGATOR

  • Jari Laukkanen, MD, PhD

    University of Eastern Finland

    STUDY DIRECTOR

Central Study Contacts

Jari Laukkanen, MD, PhD

CONTACT

+358505053013jariantero.laukkanen@uef.fi

Merja Perhonen, MD, PhD

CONTACT

+358406624456merja.perhonen@hyvaks.fi

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, cardiologist

Study Record Dates

First Submitted

January 21, 2026

First Posted

February 24, 2026

Study Start

October 30, 2025

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2028

Last Updated

February 24, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

FI(4)