Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery

NCT07429916 | Recruiting Early Phase 1

• 1 other identifier: Dec2025/189-19
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Shoulder pain is a well-recognized complaint following laparoscopic surgery. It is underlying mechanism has various causes, therefore, modalities in management and prevention of this sort of pain are numerous with different success rates. In the light of this, the investigators aim to compare an anesthetic management plan involving using ketamine (which is a known intraoperative anesthetic agent) to another not involving it for participants undergoing gastric sleeve, and compare the incidence and intensity of shoulder pain afterwards.

Conditions

Pain Management; Laparascopic Sleeve Gastrectomy

Keywords

Shoulder pain; ketamine; Postoperative; Gastrectomy

Outcome Measures

Primary Outcomes (2)

• Postoperative analgesic effect of ketamine using VAS scale

  The significance of this research is to assess the role of involving ketamine in the anesthetic plan intraoperatively in reducing postoperative shoulder pain in patients undergoing laparoscopic gastric sleeve. The visual analog scale (VAS) is a pain rating scale. Scores are based on self-reported measures of symptoms that are recorded were 0 there is no pain, and 10 is the worst pain.

  6 months

• Postoperative analgesic effect of ketamine using COMFORT scale

  The Comfort scale is a behavioural method of measuring distress and pain. This scale has eight indicators: alertness, calmness / agitation, respiratory response, physical movement, blood pressure, heart rate, muscle tone, facial tension. Each indicator is scored between 1 and 5 based. Participants would be observed during the postoperative course. The total score can range between 8 to 40. A score of 17 to 26 generally indicates adequate sedation and pain control.

  6 MONTHS

Study Arms (2)

Ketamine group

EXPERIMENTAL

Drug: Intraoperative ketamine

no intervention

NO INTERVENTION

Interventions

Intraoperative ketamine DRUG

intra-operative intravenous ketamine infusion in a dose of 0.3mg/kg/hour

Ketamine group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• patients aged 18-60
• American society of anesthesiologist grade 1,2
• BMI \> 40
• BMI \> 35 with obesity-related comorbidities

You may not qualify if:

• mentally incapacitated
• patients received any type of analgesia 24hr preoperatively except paracetamol
• history of drug abuse
• patients with low ejection fraction

Sponsors & Collaborators

• King Abdullah University Hospital: lead
• Jordan University of Science and Technology: collaborator

Study Sites (1)

King Abdullah University Hospital

Irbid, 22110, Jordan

RECRUITING

MeSH Terms

Conditions

Agnosia; Shoulder Pain

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Arthralgia; Joint Diseases; Musculoskeletal Diseases; Pain

Central Study Contacts

Anas Alrusan

CONTACT

+962797015888; amalrusan@just.edu.jo

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Anesthesia

Study Record Dates

• First Submitted: January 30, 2026
• First Posted: February 24, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

JO (1)