Assessment of Topical Application of Chitosan 0.2% Chlorhexidine Gel on Wound Healing in Diabetic Patients

NCT07429812 | Enrolling By Invitation

• 1 other identifier: SCBR-514/2025
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Despite efforts to prevent postoperative discomfort, immediate side effects of surgical extraction of lower molars include bleeding at the site of extraction, inflammation, pain, and alveolar osteitis especially in diabetic patients Bexident Post is a topical gel commercialized by ISDIN labs (ISDIN, Spain) that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. it has hemostatic, antimicrobial, wound healing properties and proven antiseptic effect.

Conditions

Extraction Socket Healing

Keywords

Wound healing; Chitosan gel; Surgical extraction

Outcome Measures

Primary Outcomes (3)

• Early Wound Healing Score (EHS)

  The Early Wound Healing Score (EHS) is a 0-10 point clinical tool designed to objectively assess the quality of periodontal soft tissue healing

  3 days,1 week, 2 weeks, 1 month

• Visual analog scale

  0 represent no pain and 10 represenet severe pain

  3 days,1 week, 2 weeks, 1 month.

• Swelling

  Intraoral swelling score (Edema)

  3 days,1 week, 2 weeks, 1 month

Study Arms (1)

Surgical extraction of the offending tooth will be performed under local anesthesia using inferior a

OTHER

Surgical extraction of the offending tooth will be performed under local anesthesia using inferior alveolar nerve block technique with buccal mucosa infiltration, make an incision on the gingival tissue (envelop flap) and , make bone guttering reduction and tooth sectioning and tooth is removed using dental elevators. control group : only instruction no gel will be used

Procedure: Surgical extraction of the offending tooth will be performed under local anesthesia using inferior alveolar nerve block technique with buccal mucosa infiltration, make an incision on the gingival tis

Interventions

Surgical extraction of the offending tooth will be performed under local anesthesia using inferior alveolar nerve block technique with buccal mucosa infiltration, make an incision on the gingival tis PROCEDURE

Surgical extraction of the offending tooth will be performed under local anesthesia using inferior alveolar nerve block technique with buccal mucosa infiltration, make an incision on the gingival tissue (envelop flap) and , make bone guttering reduction and tooth sectioning and tooth is removed using dental elevators. Study Group: Socket filled with Chitosan + 0.2% CHX gel.

Surgical extraction of the offending tooth will be performed under local anesthesia using inferior a

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults with controlled diabetes (HbA1c \<7
• Mandibular molar extraction indicated

You may not qualify if:

• Immunocompromised, allergyto Chitosan/CHX.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Al Kharj, 16272, Saudi Arabia

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 18, 2026
• First Posted: February 24, 2026
• Study Start: October 12, 2025
• Primary Completion: February 10, 2026
• Study Completion (Estimated): September 10, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)