Effects of Play Based Neural Mobilisation Activities on Hand Grip Strength and Dexterity in Cerebral Palsy Children

NCT07428928 | Recruiting DMC

• 1 other identifier: REC/RCR&AHS/UZMAIRSHAD
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.

Conditions

Cerebral Palsy

Keywords

Cerebral palsy, Diplegic, Exercise, Hand strength, Spastic

Outcome Measures

Primary Outcomes (2)

• Hand Dynamometer for hand grip strength

  Handgrip dynamometers are employed for a wide range of purposes. Assessing general strength is the most widely used method for comparing muscular function across groups, evaluating the course of wasting disorders such as sarcopenia, and even identifying prospective deficits. In order to quantify the strength of various muscles that are directly linked to a pathological condition, such as rotator cuff strength, handgrip dynamometers are also utilized as functional evaluation instruments. Handgrip dynamometers are mostly used for evaluation in the rehabilitation process, such as monitoring general rehabilitation progress or assessing the impact of a particular rehabilitation regimen aimed at a grip strength issue, such as shoulder impingement syndrome. Strong handgrips are essential for independent and fulfilling daily functioning

  baseline, 16th weeks

• Pegboard test for Dexterity

  The functional dexterity test (FDT), a timed pegboard test that involves manipulating each peg, is appropriate for young children due to its ease of use and speed. The 16-hole wooden pegboard used for the FDT is set up in four rows of four, with each peg hole that is 2.5 cm in diameter, 3 cm deep, and 2 cm away from the neighboring peg holes. Every patient will be requested to take a seat in a chair facing the FDT pegboard on a table. The patients will be instructed to practice by flipping every peg on the board once. After the test will be completed, the examiner will note how long it take to complete the test

  baseline, 16th week

Study Arms (2)

Group A: intervention group (routine physical therapy +play based neural mobilisation)

ACTIVE COMPARATOR

movements that are advantageous for neural mobility will be used to incorporate neural mobilization. Total 20 sessions will be performed (40 min, 3 days a week)

Other: neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment.

Group B:control Group( routine physical Therapy)

ACTIVE COMPARATOR

exercises will be stretching exercises, strengthening exercises, gait training, range of motion exercises of upper and lower limbs. Total 20 sessions will be performed (40 min, 3 days a week).

Other: Regular physical therapy

Interventions

Regular physical therapy OTHER

Regular physical therapy was administered to the control group along with baseline care. These workouts included upper and lower limb range of motion activities, gait training, strengthening exercises, and stretching exercises.

Group B:control Group( routine physical Therapy)

neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. OTHER

treatment include muscle stretching, strengthening, gait training, Range of motion exercises for both upper and lower limbs. Group A will perform neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. Total 20 sessions will be performed (40 min, 3 days a week)

Group A: intervention group (routine physical therapy +play based neural mobilisation)

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Diplegic cerebral palsy patients
• Both Girls and boys included
• Age limit 6-12 years
• CP child with Gross Motor Function Classification System (GMFCS) level III and IV(20)
• CP child at MACS level II and III

You may not qualify if:

• Patients with history of injury in 1 year.
• Patients who cannot obey commands
• CP children with associated scoliosis

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Acme Medical center, Liaqat medical center

Lahore, Punjab Province, 54000, Pakistan

RECRUITING

Related Publications (1)

• Baptista FM, Cruz EB, Afreixo V, Silva AG. Effectiveness of neural mobilization on pain intensity, disability, and physical performance in adults with musculoskeletal pain-A protocol for a systematic review of randomized and quasi-randomized controlled trials and planned meta-analysis. PLoS One. 2022 Mar 10;17(3):e0264230. doi: 10.1371/journal.pone.0264230. eCollection 2022.

  PMID: 35271600 BACKGROUND

MeSH Terms

Conditions

Cerebral Palsy; Motor Activity; Muscle Spasticity

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Behavior; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Uzma Irshad, MS-PT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

IMRAN AMJAD, PhD

CONTACT

9233224390125; imran.amjad@riphah.edu.pk

Muhammad Asif javed, MS-PT

CONTACT

923224209422; a.javed@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: participants will get separate treatment protocol and possible efforts will be put to mask the both group about the treatment
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: February 24, 2026
• Study Start: October 29, 2025
• Primary Completion: February 20, 2026
• Study Completion: February 20, 2026
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)