Effects of CHRIST Among Children With Spastic CP

NCT07244146 | Recruiting DMC

• 1 other identifier: REC/RCR&AHS/FAIRY ALI
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period. Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0

Conditions

Cerebral Palsy

Keywords

Hemiplegic spastic cerebral palsy; In-hand manipulation; , Grip strength

Outcome Measures

Primary Outcomes (1)

• Jamma Dynamometer

  Grip strength will be measured by Jammar Dynamometer. The hand-held dynamometer are reliable measurement instruments to measure muscle strength of the arm and hand in children with unilateral spastic cerebral palsy, aged 7 12 years

  Baseline, 1st week and 10th week

Secondary Outcomes (1)

• Melbourne assessment 2 (MA2)

  Baseline, 1st week and 10th week

Study Arms (1)

The intervention will be comprehensive hand repetitive intense strength training

EXPERIMENTAL

CHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h. Results will be evaluated by MA2 and dynamometer.

Other: CHRIST

Interventions

CHRIST OTHER

CHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h.

The intervention will be comprehensive hand repetitive intense strength training

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Children Diagnosed with hemiplegic spastic cerebral palsy.
• Age 6-12 years.
• Capable of following commands regarding hand use and testing.
• Capable of communicating needs.
• Parents or caregivers willing to provide informed consent and participate in the study.
• No contraindications to moderate physical activity.
• Able to lift the more affected arm 15 cm above a table surface and grasp light objects

You may not qualify if:

• Children with musculoskeletal system injuries, including upper limb fractures or contractures, as well as those who had received medications affecting muscle strength or spasticity, were excluded from the study.
• Orthopedic surgery involving the more affected hand within the past 6 months.
• Children with Cardiovascular disease.
• Lack of cooperation with instructions or other behavioral challenges that prevent effective delivery of intensive therapy.
• Visual impairments that may hinder active participation.
• Seizure or family history of seizure disorders

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Imran Amjad

Lahore, Punjab Province, 5400, Pakistan

RECRUITING

Related Publications (1)

• Lee DR, You JH, Lee NG, Oh JH, Cha YJ. Comprehensive Hand Repetitive Intensive Strengthening Training (CHRIST)-induced morphological changes in muscle size and associated motor improvement in a child with cerebral palsy: an experimenter-blind study. NeuroRehabilitation. 2009;24(2):109-17. doi: 10.3233/NRE-2009-0460.

  PMID: 19339750 BACKGROUND

MeSH Terms

Conditions

Cerebral Palsy

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• FAIRY ALI, MSPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

IMRAN AMJAD, PHD

CONTACT

9233224390125; imran.amjad@riphah.edu.pk

MUHAMMAD ASIF JAVED, MSPT

CONTACT

923224209422; a.javed@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Single (Participant) Participants will get separate treatment protocols and possible efforts will be put to mask the both group about the treatment.
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period. Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 24, 2025
• Study Start: October 22, 2025
• Primary Completion (Estimated): June 2, 2026
• Study Completion (Estimated): June 16, 2026
• Last Updated: November 24, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)