NCT07427316

Brief Summary

To evaluate the diagnostic performance of arterial spin labelling (ASL) magnetic resonance perfusion in preoperative grading of pediatric brain tumors.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
20mo left

Started Mar 2026

Typical duration for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress20%
Mar 2026Apr 2028

First Submitted

Initial submission to the registry

February 17, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 23, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2028

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2028

Last Updated

February 23, 2026

Status Verified

February 1, 2026

Enrollment Period

2 years

First QC Date

February 17, 2026

Last Update Submit

February 20, 2026

Conditions

Pediatric Brain Tumors

Keywords

ASL MRIarterial spin labellingmagnetic resonance perfusion

Outcome Measures

Primary Outcomes (1)

  • Evaluate the diagnostic value of arterial spin labelling (ASL) magnetic resonance perfusion in pre-operative grading of pediatric brain tumors

    arterial spin labelling (ASL) derived cerebral blood flow values and their correlation with histopathological tumor grade (low grade versus high grade pediatric brain tumor)

    preoperative

Study Arms (2)

low grade pediatric brain tumors

high grade pediatric brain tumors

Eligibility Criteria

Age0 Years - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

pediatric patients with radiological diagnosis of brain tumors

You may qualify if:

  • Pediatric patients aged 18 years or younger.
  • Patients with radiological diagnosis of intracranial brain tumors.

You may not qualify if:

  • Patients who have received prior surgery, chemotherapy or radiotherapy for brain tumors.
  • Patients with contraindications to magnetic resonance imaging (MRI) examination.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (5)

  • Kong L, Chen H, Yang Y, Chen L. A meta-analysis of arterial spin labelling perfusion values for the prediction of glioma grade. Clin Radiol. 2017 Mar;72(3):255-261. doi: 10.1016/j.crad.2016.10.016. Epub 2016 Dec 6.

    PMID: 27932251BACKGROUND

  • Morana G, Tortora D, Stagliano S, Nozza P, Mascelli S, Severino M, Piatelli G, Consales A, Lequin M, Garre ML, Rossi A. Pediatric astrocytic tumor grading: comparison between arterial spin labeling and dynamic susceptibility contrast MRI perfusion. Neuroradiology. 2018 Apr;60(4):437-446. doi: 10.1007/s00234-018-1992-6. Epub 2018 Feb 16.

    PMID: 29453753BACKGROUND

  • Dangouloff-Ros V, Deroulers C, Foissac F, Badoual M, Shotar E, Grevent D, Calmon R, Pages M, Grill J, Dufour C, Blauwblomme T, Puget S, Zerah M, Sainte-Rose C, Brunelle F, Varlet P, Boddaert N. Arterial Spin Labeling to Predict Brain Tumor Grading in Children: Correlations between Histopathologic Vascular Density and Perfusion MR Imaging. Radiology. 2016 Nov;281(2):553-566. doi: 10.1148/radiol.2016152228. Epub 2016 Jun 3.

    PMID: 27257950BACKGROUND

  • Furtner J, Schopf V, Schewzow K, Kasprian G, Weber M, Woitek R, Asenbaum U, Preusser M, Marosi C, Hainfellner JA, Widhalm G, Wolfsberger S, Prayer D. Arterial spin-labeling assessment of normalized vascular intratumoral signal intensity as a predictor of histologic grade of astrocytic neoplasms. AJNR Am J Neuroradiol. 2014 Mar;35(3):482-9. doi: 10.3174/ajnr.A3705. Epub 2013 Aug 14.

    PMID: 23945226BACKGROUND

  • Yeom KW, Mitchell LA, Lober RM, Barnes PD, Vogel H, Fisher PG, Edwards MS. Arterial spin-labeled perfusion of pediatric brain tumors. AJNR Am J Neuroradiol. 2014 Feb;35(2):395-401. doi: 10.3174/ajnr.A3670. Epub 2013 Aug 1.

    PMID: 23907239BACKGROUND

Study Officials

  • Mostafa Elsharkawy, Professor

    Assiut university hospitals

    STUDY CHAIR

  • Radwa Kamel, associate professor

    Assiut university hospitals

    STUDY DIRECTOR

  • Hamdy Ibrahim

    Assiut university hospitals

    STUDY DIRECTOR

Central Study Contacts

Monica Boles

CONTACT

+20 01278489110monica.sobhy94@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor

Study Record Dates

First Submitted

February 17, 2026

First Posted

February 23, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

March 1, 2028

Study Completion (Estimated)

April 1, 2028

Last Updated

February 23, 2026

Record last verified: 2026-02