Comparisons of Efficacy of Triphala and Chlorhexidine Mouthwash Against Plaque Accumulation and Gingivitis.

NCT07426393 | Completed

• 1 other identifier: BSMMU/2024/6798
• Study Type: interventional
• Target: 220
• Locations: 1 country
• Sites: 1

Brief Summary

Gingivitis is one of the commonly prevalent oral diseases worldwide which is caused by the bacterial biofilm adhering to the teeth surfaces. Chlorhexidine is the antimicrobial agent most familiar to dental professionals. The need for frequent application of Chlorhexidine and other side effects such as unpleasant taste and staining has stimulated the search for alternatives. "Triphala" is among the most common formulas used in Traditional Ayurvedic Medicine. Triphala has an antibacterial effect. In this context, a study was undertaken to ascertain the effects of a mouthwash prepared with Triphala on the oral health status and compare it with commercially available Chlorhexidine mouthwash.

Conditions

Gingivitis

Outcome Measures

Primary Outcomes (3)

• PIaque Index

  plaque index 0:no plaque is in the area adjacent to the gingiva plaque index 1:there is a plaque in the form of a thin film on the gingival margin plaque index 2:there is a visible plaque in the gingival pocket and gingival margin plaque index 3:there is a dense plaque in the gingival pocket and gingival margin

  30 days

• Gingival Index

  Gingival index 0: Healthy gums. Gingival index 1: Mild discolouration and oedematous gingiva. No bleeding on probing. Gingival index 2: Red, oedematous and shiny gingiva. There is bleeding on probing. Gingival index 3: Red, oedematous and ulcerated gingiva. There is spontaneous bleeding.

  30 days

• BIeeding Index

  30 days

Study Arms (2)

6% Triphala mouthwash

EXPERIMENTAL

Experimental: 15ml of 6%Triphala mouthwash twice daily for 30 days.

Other: 6% Triphala mouthwash

placebo Comparator:Placebo Participants received 15 ml of 6% chlorhexidine mouthwash

PLACEBO COMPARATOR

placebo Participants received 15 ml mouthwash twice daily for 30 days

Other: .2% chlorhexidine mouthwash

Interventions

.2% chlorhexidine mouthwash OTHER

participants received 15 ml of .2% chlorhexidine mouthwash twice daily for 30 days

placebo Comparator:Placebo Participants received 15 ml of 6% chlorhexidine mouthwash

6% Triphala mouthwash OTHER

participants received 15 ml of 6% triphala mouthwash twice daily for 30 days

6% Triphala mouthwash

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age groups of 18-45 years with
• Mild to moderate gingivitis,
• Patients with a minimum of 20 teeth, and
• Patients who have not undergone periodontal treatment in the past 6 months.

You may not qualify if:

• Use of anti-inflammatory drugs and antibiotics in previous 6 months;
• Individuals with prosthetic appliances or orthodontic appliances that would interfere with evaluation
• Allergy to Triphala and Chlorhexidine used in the study;
• Smokers or users of tobacco in any form
• Lactating females or pregnant women
• Mental-retarded patients.

Sponsors & Collaborators

• Bangladesh Medical University: lead

Study Sites (1)

Bangladesh Medical University

Dhaka, Bangladesh

Location

MeSH Terms

Conditions

Gingivitis

Condition Hierarchy (Ancestors)

Infections; Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Model Details: 220 individuals with chronic generalized gingivitis were recruited from the Outpatient Department of BMU, Dhaka. The current study was designed as a randomized control trial. * Group A: n = 110 was given Triphala mouthwash * Group B: n = 110 was given Chlorhexidine mouthwash

Study Record Dates

• First Submitted: February 9, 2026
• First Posted: February 23, 2026
• Study Start: March 15, 2025
• Primary Completion: August 31, 2025
• Study Completion: November 30, 2025
• Last Updated: February 23, 2026

Record last verified: 2024-07

Locations

BA (1)