Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery

NCT07422025 | Active Not Recruiting

• 1 other identifier: RC 20.1.2026
• Study Type: observational
• Target: 149
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients undergoing lower limb orthopedic surgery. The study seeks to determine if these preoperative scores can accurately identify patients at higher risk for 90-day mortality and major complications.

Conditions

Lower Limb Fracture

Outcome Measures

Primary Outcomes (2)

• Percentage of Participants With Major Postoperative Complications

  The number of participants who experienced one or more major postoperative complications, defined as Clavien-Dindo Grade III or higher.

  90 days post-surgery

• Diagnostic Accuracy of the Risk Analysis Index (RAI)

  The Area Under the Receiver Operating Characteristic (ROC) curve used to determine the predictive performance of the RAI score for 90-day mortality.

  90 days post-surgery

Secondary Outcomes (1)

• Correlation of Surgical Apgar Score (SAS) with Recovery

  1 week

Study Arms (2)

Frail Group

Geriatric patients (aged 65+) identified as "frail" based on preoperative Risk Analysis Index (RAI) or 5-mFI scores.

Other: Preoperative Frailty Scoring

Non-Frail Group

Geriatric patients undergoing similar lower limb surgeries who are identified as "robust" or "non-frail" by the same assessment tools.

Other: Preoperative Frailty Scoring

Interventions

Preoperative Frailty Scoring OTHER

Data extraction of RAI and 5-mFI scores from medical records to correlate with 90-day postoperative outcomes.

Frail Group; Non-Frail Group

Eligibility Criteria

• Age: 65 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of geriatric patients aged 65 years and older who underwent major lower limb orthopedic surgeries (such as hip or knee arthroplasty or fracture fixation) at the participating orthopedic departments. The cohort includes individuals with varying degrees of preoperative physical reserve, categorized into frail, pre-frail, and non-frail groups using validated assessment tools. This population represents a high-risk surgical demographic characterized by multiple comorbidities and age-related physiological decline, requiring detailed perioperative data analysis.

You may qualify if:

• Geriatric patients (aged 65 years and older).
• Underwent lower limb orthopedic surgery (e.g., hip or knee arthroplasty, fracture fixation).
• Availability of complete perioperative medical records.

You may not qualify if:

• Patients younger than 65.
• Incomplete follow-up data or missing intraoperative records.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Benha University

Banhā, Al Qalyoubia, 13511, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Orthopedic Surgery, Faculty of Medicine, Benha University.

Study Record Dates

• First Submitted: February 8, 2026
• First Posted: February 19, 2026
• Study Start: February 1, 2026
• Primary Completion: March 1, 2026
• Study Completion: April 1, 2026
• Last Updated: February 23, 2026

Record last verified: 2026-02

Locations

EG (1)