Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma

NCT07418775 | Recruiting

• 3 other identifiers: 25109NCI-2026-005761U54CA302452-01
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

Meningiomas are the most common primary brain tumor, and some groups are diagnosed with higher-grade tumors and have clinically worse outcomes. This study investigates social determinants of health and individual risk factors that may be associated with meningioma.

Conditions

Meningioma of Brain; Meningioma; Brain Tumor

Outcome Measures

Primary Outcomes (3)

• Identifying potential social and structural determinants of health (SSDH)

  The prevalence of SSDH factors such as race and ethnicity, birthplace, relationship status, sexual orientation/gender identity, education level, socio-economic status, access to care, reproductive/menstrual history, health factors and medication use, chemical and radiation exposure, smoking history, and perceived stress for participants with meningioma will be analyzed using multilevel logistic and linear models accounting for geographical clustering.

  Up to 5 years

• Distribution of social and structural determinants of health

  The distribution of SSDH factors across racial groups will be analyzed using multilevel logistic and linear models accounting for geographical clustering.

  Up to 5 years

• Identify disparities in social and structural determinants of health (SSDH)

  Disparities of SSDH factors across racial groups will be analyzed using multilevel logistic and linear models accounting for geographical clustering.

  Up to 5 years

Study Arms (1)

Participants with Meningioma

Adult patients who have been diagnosed with a meningioma will be asked to complete a one-time survey, which will take roughly 20 minutes to complete. Participants will also have medical records reviewed to capture additional data relating to the participants medical history.

Behavioral: Questionnaire; Other: Medical Record Review

Interventions

Questionnaire BEHAVIORAL

A questionnaire will be administered in person or online

Participants with Meningioma

Medical Record Review OTHER

Medical records will be reviewed for study specific data collection

Participants with Meningioma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult participants receiving care at the University of California, San Francisco who have been diagnosed with meningioma.

You may qualify if:

• Adults ≥18 years of age
• Able to speak and read English
• Diagnosed with a meningioma

You may not qualify if:

• Active psychiatric issues (suicidality, active psychosis, grave disability, etc.)
• Inability to consent secondary to severe neurologic deficit or psychiatric distress
• Inability to complete survey secondary to severe neurologic deficit or psychiatric distress

Sponsors & Collaborators

• National Cancer Institute (NCI): collaborator
• University of California, San Francisco: lead

Study Sites (1)

University of California San Francisco

San Francisco, California, 94143, United States

RECRUITING

MeSH Terms

Conditions

Meningioma; Brain Neoplasms

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Neoplasms, Nerve Tissue; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Vascular Tissue; Meningeal Neoplasms; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Nervous System Diseases; Brain Diseases; Central Nervous System Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• David Raleigh, MD, PhD

  University of California, San Francisco, San Francisco, California 94143

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zora Arum

CONTACT

877-827-3222; zora.arum2@ucsf.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 11, 2026
• First Posted: February 18, 2026
• Study Start: January 16, 2026
• Primary Completion (Estimated): January 1, 2031
• Study Completion (Estimated): January 1, 2032
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)