Impact of New-onset Insomnia After Coronary Revascularization for Patients With Acute Myocardial Infarction

NCT07416617 | Not Yet Recruiting

• 1 other identifier: MI_Insomnia
• Study Type: observational
• Target: 235,342
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aimed to evaluate the impact of acute insomnia on long-term clinical outcomes in patients underwent PCI or CABG for AMI using the Korean National Health Insurance Service (NHIS) database, and to identify the factors through which insomnia contributes to prognostic determination in this patient population.

Conditions

Insomina; Acute Myocardial Infarction

Keywords

acute myocardial infarction; insomnia

Outcome Measures

Primary Outcomes (1)

• Rates of MACCE

  a composite of death, spontaneous MI, repeat revascularization, and ischemic stroke

  up to 10 years

Secondary Outcomes (4)

• Rates of Death

  up to 10 years

• Rates of Revascularization

  up to 10 years

• Rates of Spontaneous MI

  up to 10 years

• Rates of Ischemic stroke

  up to 10 years

Study Arms (2)

No insomina

patient did not have insomia

Insomnia

patient have insomnia

Drug: Insomnia medication; Other: No insomnia medication

Interventions

Insomnia medication DRUG

Diagnosed as insomnia and use of anti-insomnia medication

Insomnia

No insomnia medication OTHER

Diagnosed as insomnia and did not use of anti-insomnia medication

Insomnia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

dults aged ≥18 years who were hospitalized between January 1, 2009, and December 31, 2023, with a primary diagnosis of AMI, defined using ICD-10 codes I21-I23 along with procedure codes for revascularization (either PCI or CABG), were included (N = 318,356). Among the participants, we excluded patients with mental disorder prior to incident MI (N =79,133), and patients who die at the diagnosis of AMI (N = 3,881).

You may qualify if:

• Diagnosis of acute myocardial infarction
• Undergoing percutaneous coronary intervention or coronary artery bypass surgery

You may not qualify if:

• Pre-existing phychiatric disorders

Sponsors & Collaborators

• Samsung Medical Center: lead

Study Sites (1)

Samsung Medical Center

Seoul, 06351, South Korea

Location

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Central Study Contacts

Ki Hong Choi, MD, PhD

CONTACT

+82234100897; cardiokh@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 10, 2026
• First Posted: February 18, 2026
• Study Start: February 12, 2026
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)