PPV vs PVI in the Supine and Prone Position

NCT07415603 | Not Yet Recruiting

• 1 other identifier: STUDY00005745
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol. The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

Conditions

Surgeries Undergoing General Anesthesia

Outcome Measures

Primary Outcomes (4)

• PPV Supine

  Pulse Pressure Variability (PPV) recorded from the arterial line while supine.

  Once a minute for 5 minutes

• PVI Supine

  Plethysmography Variability Index (PVI) recorded from the pulse oximeter while supine.

  Once a minute for 5 minutes

• PPV Prone

  Pulse Pressure Variability (PPV) recorded from the arterial line while prone.

  Once a minute for 5 minutes

• PVI Prone

  Plethysmography Variability Index (PVI) recorded from the pulse oximeter while prone.

  Once a minute for 5 minutes

Study Arms (1)

Prone surgical patients

Other: Observation

Interventions

Observation OTHER

No intervention

Prone surgical patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing surgery at Nationwide Children's Hospital only.

You may qualify if:

• Consenting ASA 1-4 patients
• Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning

You may not qualify if:

• Patients in whom an arterial cannula is not indicated or cannot be placed
• Patients undergoing a surgical procedure that does not require prone positioning

Sponsors & Collaborators

• Joseph D. Tobias: lead

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Joseph Tobias, MD

  Nationwide Children's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Julie Rice-Weimer, BSN

CONTACT

614-355-3142; julie.rice-weimer@nationwidechildrens.org

Catherine Roth, MPH

CONTACT

catherine.roth@nationwidechildrens.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Chief - Department of Anesthesiology & Pain Medicine

Study Record Dates

• First Submitted: February 10, 2026
• First Posted: February 17, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): May 31, 2029
• Study Completion (Estimated): May 31, 2029
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share