Laser-assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation

NCT07415434 | Completed

• 1 other identifier: 2022/419
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized placebo-controlled clinical trial aimed to evaluate the effect of laser-assisted therapy on soft tissue healing at the pontic site prior to fixed partial denture rehabilitation. Clinical healing outcomes, postoperative pain levels, and gingival crevicular fluid transforming growth factor beta-2 (TGF-β2) levels were assessed to determine the biological and clinical effects of laser therapy compared with placebo.

Conditions

Soft Tissue Healing

Keywords

fixed partial denture; pontic site; low-level laser therapy; clinical trial

Outcome Measures

Primary Outcomes (1)

• Clinical healing index (Landry, Turnbull and Howley Healing Index)

  Clinical healing was assessed using the Landry, Turnbull and Howley Healing Index, which provides a single composite ordinal score ranging from 1 to 5, where higher scores indicate better soft tissue healing. The score is determined based on clinical evaluation of tissue color, bleeding on palpation, presence of granulation tissue, and degree of epithelialization at the pontic site.

  Baseline, Day 7, Day 14

Secondary Outcomes (3)

• Wound size reduction

  Baseline, Day 7, Day 14

• Postoperative pain (VAS)

  Baseline, Day 7, Day 14

• Gingival crevicular fluid TGF-β2 levels

  Baseline, Day 7, Day 14

Study Arms (3)

GRR Laser

EXPERIMENTAL

Laser therapy applied once daily for five consecutive days following tooth extraction.

Device: GRR laser

Nd:YAG Laser

EXPERIMENTAL

Nd:YAG laser therapy applied once daily for five consecutive days following tooth extraction.

Device: Nd:YAG laser

Placebo

PLACEBO COMPARATOR

Sham laser application performed under identical conditions without energy delivery.

Other: Sham laser

Interventions

GRR laser DEVICE

Low-level laser therapy applied once daily for five consecutive days following tooth extraction to enhance soft tissue healing at the pontic site.

GRR Laser

Nd:YAG laser DEVICE

Nd:YAG laser therapy applied once daily for five consecutive days following tooth extraction to promote soft tissue healing.

Nd:YAG Laser

Sham laser OTHER

Placebo laser application performed under identical conditions without energy delivery.

Placebo

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older
• Patients requiring single-tooth extraction followed by fixed partial denture rehabilitation
• Patients in good general health
• Patients willing to participate and able to provide informed consent

You may not qualify if:

• Presence of systemic diseases that may affect wound healing (e.g., uncontrolled diabetes, immunological disorders)
• Active periodontal disease at the study site
• Use of medications affecting wound healing
• Smoking or tobacco use
• Pregnancy or lactation
• History of radiotherapy in the head and neck region
• Known contraindications to laser therapy

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

Gaziantep University Faculty of Dentistry

Gaziantep, Turkey, 27310, Turkey (Türkiye)

Location

Study Officials

• İREM KARAGÖZOĞLU

  University of Gaziantep

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist.prof.

Study Record Dates

• First Submitted: February 9, 2026
• First Posted: February 17, 2026
• Study Start: March 15, 2025
• Primary Completion: May 15, 2025
• Study Completion: June 15, 2025
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)