Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4

NCT07414680 | Recruiting

• 1 other identifier: 202501674B0A3
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 2

Brief Summary

This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.

Conditions

Cognitive Change; Aging; Sleep Disturbance

Keywords

dementia; depression; brain structure; system biology

Outcome Measures

Primary Outcomes (1)

• The brain volume of local Taiwanese aged over 40 years old

  Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging

  one hour

Secondary Outcomes (16)

• The actigraphy of local Taiwanese aged over 40 years old

  two weeks

• The sleep quality questionnaire of local Taiwanese aged over 40 years old

  one day

• The gut microbiota of local Taiwanese aged over 40 years old

  one day

• The metabolism of local Taiwanese aged over 40 years old

  one day

• The metabolism of local Taiwanese aged over 40 years old

  one day

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

By collecting data from participants in the "Integrating Systemic Geriatric Medical Information to Explore Solutions for Healthy Aging (Pilot Project)," the "Integrating Systemic Geriatric Medical Information to Explore Solutions for Healthy Aging" main project, and the "Integrating Systemic Medical Information to Explore Solutions for Healthy Aging" project, approximately 100 individuals aged 60 and above, residing in Songshan District of Taipei City, Chang Gung Health and Wellness Village, and Senior Citizens' Health Activity Centers (Shuanglian, New Taipei City; Delai, Taoyuan City), were included. Additionally, 100-150 middle-aged employees aged 40-59 from Chang Gung Hospital, Formosa Plastics Group, and Chang Gung University were also included.

You may qualify if:

• Willing to sign a written participant consent form.

You may not qualify if:

• Males or females aged 40-59 who have participated in health checkups for employees of Chang Gung Memorial Hospital, Formosa Plastics Group, or Chang Gung University.
• Those with a medical record of more than one year at Chang Gung Memorial Hospital.
• Those who have resided in Taiwan for more than 180 days in the past year.
• Individuals with severe organ abnormalities, such as: heart failure (NYHA Fc ≥ III), chronic obstructive pulmonary disease (hospitalization/emergency room visit or medication adjustment within the past month due to disease worsening), decompensated cirrhosis, hemodialysis, or currently undergoing cancer treatment.
• Individuals with a history of severe autoimmune diseases.
• Individuals with a preliminary cognitive and mental assessment score of \<26 on the Mini-Mental State Examination (MMSE) or ≥5 on the Generalized Depression Scale (GDS).
• Individuals (who agree to undergo brain MRI) who are deemed unsuitable for MRI after evaluation (e.g., those with pacemakers, cochlear implants, or spatial phobia).
• Individuals who have taken antibiotics within the past month.
• Individuals whose hearing, vision, or cognitive impairments affect communication.
• Individuals unable to stand or walk (with a walking aid) or with unsteady gait when walking.
• Those who have undergone follow-up outpatient assessments that may affect cognitive function, including but not limited to stroke, Parkinson's syndrome, Parkinson's dementia, epilepsy, brain tumor, or a history of mental illness such as schizophrenia, severe depression, bipolar disorder, alcohol or drug abuse, or a history of loss of consciousness due to severe head trauma.
• Those currently diagnosed with depression and undergoing treatment.
• Those with a past medical history confirming dementia, depression, etc..
• Those deemed unsuitable by a physician.

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead
• Chang Gung University: collaborator

Study Sites (2)

Taipei Chang Gung Memorial Hospital

Taipei, 105, Taiwan

RECRUITING

Taoyuan Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Biospecimen Description: blood, urine, and stool

MeSH Terms

Conditions

Parasomnias; Dementia; Depression

Condition Hierarchy (Ancestors)

Sleep Wake Disorders; Nervous System Diseases; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Neurocognitive Disorders; Behavioral Symptoms; Behavior

Central Study Contacts

JI-TSENG FANG, Professor

CONTACT

+886-3-3281200; fangjits@cgmh.org.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 23, 2026
• First Posted: February 17, 2026
• Study Start (Estimated): September 15, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: July 30, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TW (2)