Mastication, Cognition, and Nutritional Status in Multiple Sclerosis

NCT07411924 | Not Yet Recruiting

• 1 other identifier: 2025/283
• Study Type: observational
• Target: 86
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to investigate the relationship between chewing function and cognitive functions, disease severity, and nutritional status in individuals diagnosed with Multiple Sclerosis

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (6)

• Expanded Disability Status Scale (EDSS)

  Baseline

• Montreal Cognitive Assessment (MoCA)

  Baseline

• Turkish version of the Eating Assessment Scale (T-EAT-10)

  Baseline

• Dysphagia in Multiple Sclerosis (DYMUS)

  Baseline

• Test of Masticating and Swallowing Solids (TOMASS)

  Baseline

• Mini Nutritional Assessment Short Form (MNA)

  Baseline

Study Arms (1)

Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population will consist of individuals aged 18 years and older diagnosed with Multiple Sclerosis who are followed up at the neurology outpatient clinics.

You may qualify if:

• Being 18 years of age or older

You may not qualify if:

• Having a neurological or systemic disease other than Multiple Sclerosis that may affect chewing function
• Inability to provide adequate communication or cooperation due to psychiatric disorders
• Not being diagnosed with Multiple Sclerosis
• Not volunteering to participate in the study
• Presence of severe problems preventing questionnaire administration (visual and/or hearing impairments)
• History or presence of psychiatric and/or other neurological disorders
• Presence of severe neurological findings that may negatively affect cognitive performance (e.g., severe optic neuritis)
• Use of medications affecting cognitive functions
• Alcohol or substance use
• Having experienced a relapse within the last month
• Having received corticosteroid treatment within the last month
• History of stroke, head and neck cancer, or rheumatic diseases that may affect swallowing and chewing performance

Sponsors & Collaborators

• Ondokuz Mayıs University: lead

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Seda Nur Kemer, PhD

CONTACT

+905467861866; sedakemer@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, PT, PhD

Study Record Dates

• First Submitted: February 9, 2026
• First Posted: February 17, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: February 17, 2026

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share