Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis

NCT07410663 | Active Not Recruiting

• 1 other identifier: HA+AA-LE-001
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective, controlled clinical study aims to evaluate the effectiveness of a targeted biological support injection containing a hyaluronic acid and amino acid combination in patients with chronic lateral epicondylitis (tennis elbow). Medical records will be reviewed to compare outcomes between patients treated in routine clinical practice with a 3-dose injection regimen (weeks 0, 2, and 4) plus a home exercise program and those treated with a home exercise program alone. Key outcome measures include pain intensity (VAS), functional status (PRTEE), grip strength, and pressure pain threshold.

Conditions

Lateral Epicondylitis

Outcome Measures

Primary Outcomes (1)

• Change in Pain Intensity (VAS)

  Pain intensity will be measured using a 10-cm Visual Analog Scale (VAS).

  Baseline, Week 4, and Month 3

Secondary Outcomes (3)

• Change in Pressure Pain Threshold (Algometry)

  Baseline, Week 4, and Month 3

• Change in Functional Status (PRTEE Score)

  Baseline, Week 4, and Month 3

• Change in Grip Strength (Hand Dynamometer)

  Baseline, Week 4, and Month 3

Study Arms (2)

Control Group: Home Exercise Program Only

Home exercise program without injection.

Behavioral: Home Exercise Program

Intervention Group: HA+AA Injection + Home Exercise Program

Patients in this retrospective cohort were treated with a targeted biological support injection (Hyaluronic Acid and Amino Acid combination) administered at weeks 0, 2, and 4, in addition to the standardized home exercise program.

Drug: Hyaluronic Acid + Amino Acid Injection; Behavioral: Home Exercise Program

Interventions

Hyaluronic Acid + Amino Acid Injection DRUG

3-dose injection protocol administered at weeks 0, 2, and 4.

Intervention Group: HA+AA Injection + Home Exercise Program

Home Exercise Program BEHAVIORAL

Standardized home exercise program for chronic lateral epicondylitis.

Control Group: Home Exercise Program Only; Intervention Group: HA+AA Injection + Home Exercise Program

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with chronic Lateral Epicondylitis who applied to the Physical Medicine and Rehabilitation outpatient clinic of Sivas State Hospital. The study involves the retrospective analysis of patients treated between June 01, 2025, and November 01, 2025.

You may qualify if:

• Patients aged between 18 and 70 years.
• Patients diagnosed with Lateral Epicondylitis (LE).
• Presence of symptoms persisting for 6 weeks or longer.
• Patients who were treated with either a 3-dose protocol of Hyaluronic Acid + Amino Acid injection combined with a home exercise program, or a home exercise program alone.

You may not qualify if:

• History of rheumatic disease.
• History of malignancy.
• Presence of radiculopathy or neuropathy.
• Presence of peripheral circulatory disorders.
• Congenital or acquired upper extremity deformities.
• History of coagulopathy or current use of warfarin therapy.
• Presence of prosthesis, metal implant, or internal fixator in the elbow region.

Sponsors & Collaborators

• Sivas State Hospital: lead

Study Sites (1)

Sivas State Hospital

Sivas, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Tennis Elbow

Interventions

Hyaluronic Acid; Amino Acids

Condition Hierarchy (Ancestors)

Elbow Tendinopathy; Tendinopathy; Muscular Diseases; Musculoskeletal Diseases; Elbow Injuries; Arm Injuries; Wounds and Injuries; Tendon Injuries

Intervention Hierarchy (Ancestors)

Glycosaminoglycans; Polysaccharides; Carbohydrates; Amino Acids, Peptides, and Proteins

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: February 7, 2026
• First Posted: February 13, 2026
• Study Start: December 1, 2025
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)