Assessment of Informal Support Provided by Caregivers at Different Stages of Alzheimer's Disease

NCT07409506 | Recruiting

• 2 other identifiers: 25-515269HCL24_1258
• Study Type: observational
• Target: 312
• Locations: 1 country
• Sites: 1

Brief Summary

In France, approximately 1,200,000 people aged 65 and over suffer from Alzheimer's disease or related disorders, of which Alzheimer's disease (AD) accounts for 70% of cases. This prevalence could double by 2050. The cognitive decline and progression to functional dependence that accompany AD are associated with a decline in quality of life, an increased risk of comorbidities, institutionalization, and mortality, as well as high care costs, placing a burden on the patient, their family and friends, and the healthcare system. Informal care, i.e., care provided by a family member or caregiver, plays an important role in the overall management of major neurocognitive disorders (NCDs) associated with AD at home. In France, the annual cost of informal care for AD was estimated in 2008 at around €14 billion per year, or approximately 50% of the total annual cost of AD. The economic valuation of informal care serves to inform public decision-makers not only about the cost of this resource, but also about its usefulness. The issue of resource allocation (particularly the daily allowance for family caregivers - AJPA in French) at the societal level and the sharing of private (role of caregivers) and public (role of the state and local authorities) responsibilities leads us to question the determinants of this usefulness, particularly the clinical determinants in AD patients at different stages of the disease. The main hypothesis is that informal care varies according to cognitive decline and loss of autonomy, independently or in interaction with the number and type of the patient's comorbidities, their behavioral disorders, and the caregiver's burden.

Conditions

Elderly (People Aged 65 or More); Neurocognition; Alzheimer s Disease

Keywords

informal care; cost of alzheimer's disease; caregiver

Outcome Measures

Primary Outcomes (1)

• Informal care costs

  Informal care will be collected according to the " Ressources Utilisation in Dementia " (RUD) questionnaire and valued in euros using replacement cost method.

  At inclusion or 15 days maximum after inclusion.

Study Arms (1)

Patients from Charpennes Hospital

Patients from Charpennes Hospital included in the MEM-AURA cohort, accompanied by a caregiver and aged 60 years and older at inclusion with NCD due to clinically probable Alzheimer's disease and a Mini-Mental State Evaluation (MMSE) score ≤ 26 at inclusion.

Other: " Ressources Utilisation in Dementia " (RUD) questionnaire.

Interventions

" Ressources Utilisation in Dementia " (RUD) questionnaire. OTHER

Questionnaire on the use of services available to patients with dementia.

Patients from Charpennes Hospital

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients attending memory consultations at Charpennes Hospital (HCL) for cognitive complaints. Patients from Charpennes Hospital included in the MEM-AURA cohort, accompanied by a caregiver and aged 60 years and older at inclusion with NCD due to clinically probable Alzheimer's disease and a Mini-Mental State Evaluation (MMSE) score ≤ 26 at inclusion.

You may qualify if:

• Patients from Charpennes Hospital included in the MEM-AURA cohort
• Patients with dementia due to clinically probable Alzheimer's disease, regardless of stage

You may not qualify if:

• \- Patients or caregivers who have expressed their opposition to the study
• Patients living in institutions or nursing homes
• Patients protected by law (under legal protection, guardianship, or conservatorship)
• Early termination Criteria :
• \- Patients or caregivers withdrawing their consent to participate during the study

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital des Charpennes

Villeurbanne, 69100, France

RECRUITING

MeSH Terms

Interventions

Surveys and Questionnaires

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Central Study Contacts

GERVAIS F M Frédéric GERVAIS

CONTACT

0033 4 72 43 20 66; frederic.gervais02@chu-lyon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2025
• First Posted: February 13, 2026
• Study Start: September 9, 2025
• Primary Completion (Estimated): September 9, 2026
• Study Completion (Estimated): September 9, 2027
• Last Updated: February 13, 2026

Record last verified: 2026-02

Locations

FR (1)