Effects of X Box Kinect 360 in Alzheimer's Disease

NCT07673263 | Not Yet Recruiting

• 1 other identifier: 11691225SPREH
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia that accounting for 60% to 80% of all cases (Better, et al., 2023). According to world health organization (WHO), more than 55 million people globally live with dementia, and this number is expected to rise to 78 million by 2023 and 139 million by 2050 (WHO, 2021).

Conditions

Alzheimer s Disease

Keywords

Alzheimer Disease, Virtual Reality, Kinect xbox 360

Outcome Measures

Primary Outcomes (6)

• Cognition

  Cognitive function will be assessed through among mild to moderate AD patients where low values indicate decrease in cognitive ability.

  Baseline

• Cognition

  Cognitive function will be assessed through Mini- Cog among Mild to Moderate AD patients where low values indicate decrease cognitive function

  After 6 week of Intervention

• Motor Function

  Motor function will be assessed using the Timed Up and Go (TUG) Test among patients with mild to moderate Alzheimer's disease (AD), where higher scores (longer completion times) indicate poorer functional mobility

  Baseline

• Motor Function

  Motor function will be assessed using the Timed Up and Go (TUG) Test among patients with mild to moderate Alzheimer's disease (AD), where higher scores (longer completion times) indicate functional mobility

  After 6 week of intervention

• Quality of Life (QOL)

  Quality of life will be assessed using the Quality of Life in Alzheimer's Disease (QOL-AD) scale among patients with mild to moderate Alzheimer's disease. Lower scores indicate poorer quality of life, whereas higher scores indicate better perceived quality of life.

  Baseline

• Quality Of Life (QOL)

  Quality of life will be assessed using the Quality of Life in Alzheimer's Disease (QOL-AD) scale among patients with mild to moderate Alzheimer's disease. Lower scores indicate poorer quality of life, whereas higher scores indicate better perceived quality of life.

  After 6 weeks of Intervention

Study Arms (2)

Arms 1

EXPERIMENTAL

Arm Description: Game-Based Rehabilitation received total 30sessions, 30 minutes/session, 5 times/week for total 6 weeks.

Other: 3D Kinect based game

Arm 2

PLACEBO COMPARATOR

Arm Description: Conventional Rehabilitation received total 30 sessions, 30 minutes/session, 5 times/week for total 6 weeks.

Other: Conventional therapy group

Interventions

3D Kinect based game OTHER

Experimental group will receive X boc kinect 360 bomb such as match makers, traffic control, mouse mayhem, strike a pose, pizza catch, flag frenzy, follow the arrow for 30 minutes for five days a week, for six weeks.

Arms 1

Conventional therapy group OTHER

The intervention will run for 30 minutes (excluding rest period), five days a week, for six weeks (Deng, et al., 2025). The patients will take 1-2 minutes rest after 5 minutes of activity. Rest periods of 1-2 minutes after every 5 minutes of activity.

Arm 2

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Alzheimer's disease of age between 50-85 years.
• Diagnosed AD stage Mild to Moderate.

You may not qualify if:

• Undiagnosed AD patients.
• Mental or neurological conditions like schizophrenia, Parkinson's, or stroke.

Sponsors & Collaborators

• Ziauddin University: lead

Study Sites (1)

Ziauddin University

Karachi, Sindhi, Pakistan

Location

Related Publications (10)

• Cox KL, Clare L, Cyarto EV, Ellis KA, Etherton-Beer C, Southam J, Ames D, Flicker L, Almeida OP, LoGiudice D, Liew D, Vlaskovsky P, Lautenschlager NT. A Randomized Controlled Trial on the Effects of a 6-Month Home-Based Physical Activity Program with Individual Goal-Setting and Volunteer Mentors on Physical Activity, Adherence, and Physical Fitness in Inactive Older Adults at Risk of Cognitive Decline: The INDIGO Study. J Alzheimers Dis. 2021;84(1):207-226. doi: 10.3233/JAD-210479.

  PMID: 34511499 RESULT

• Cousi C, Igier V, Quintard B. French cross-cultural adaptation and validation of the Quality of Life-Alzheimer's Disease scale in Nursing Homes (QOL-AD NH). Health Qual Life Outcomes. 2021 Sep 15;19(1):219. doi: 10.1186/s12955-021-01853-2.

  PMID: 34526034 RESULT

• Conti Filho CE, Loss LB, Marcolongo-Pereira C, Rossoni Junior JV, Barcelos RM, Chiarelli-Neto O, da Silva BS, Passamani Ambrosio R, Castro FCAQ, Teixeira SF, Mezzomo NJ. Advances in Alzheimer's disease's pharmacological treatment. Front Pharmacol. 2023 Jan 26;14:1101452. doi: 10.3389/fphar.2023.1101452. eCollection 2023.

  PMID: 36817126 RESULT

• Chen C, Homma A, Mok VC, Krishnamoorthy E, Alladi S, Meguro K, Abe K, Dominguez J, Marasigan S, Kandiah N, Kim SY, Lee DY, De Silva HA, Yang YH, Pai MC, Senanarong V, Dash A. Alzheimer's disease with cerebrovascular disease: current status in the Asia-Pacific region. J Intern Med. 2016 Oct;280(4):359-74. doi: 10.1111/joim.12495. Epub 2016 Mar 16.

  PMID: 26992016 RESULT

• Cezar NOC, Ansai JH, de Andrade LP. Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol. Physiother Res Int. 2021 Apr;26(2):e1899. doi: 10.1002/pri.1899. Epub 2021 Feb 15.

  PMID: 33586858 RESULT

• Borson S, Scanlan JM, Chen P, Ganguli M. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003 Oct;51(10):1451-4. doi: 10.1046/j.1532-5415.2003.51465.x.

  PMID: 14511167 RESULT

• 2023 Alzheimer's disease facts and figures. Alzheimers Dement. 2023 Apr;19(4):1598-1695. doi: 10.1002/alz.13016. Epub 2023 Mar 14.

  PMID: 36918389 RESULT

• Appel L, Kisonas E, Appel E, Klein J, Bartlett D, Rosenberg J, Smith C. Introducing virtual reality therapy for inpatients with dementia admitted to an acute care hospital: learnings from a pilot to pave the way to a randomized controlled trial. Pilot Feasibility Stud. 2020 Oct 31;6(1):166. doi: 10.1186/s40814-020-00708-9.

  PMID: 33292729 RESULT

• Ries JD, Hutson J, Maralit LA, Brown MB. Group Balance Training Specifically Designed for Individuals With Alzheimer Disease: Impact on Berg Balance Scale, Timed Up and Go, Gait Speed, and Mini-Mental Status Examination. J Geriatr Phys Ther. 2015 Oct-Dec;38(4):183-93. doi: 10.1519/JPT.0000000000000030.

  PMID: 25621384 RESULT

• Amjad I, Toor H, Niazi IK, Pervaiz S, Jochumsen M, Shafique M, Haavik H, Ahmed T. Xbox 360 Kinect Cognitive Games Improve Slowness, Complexity of EEG, and Cognitive Functions in Subjects with Mild Cognitive Impairment: A Randomized Control Trial. Games Health J. 2019 Apr;8(2):144-152. doi: 10.1089/g4h.2018.0029. Epub 2018 Sep 21.

  PMID: 30239213 RESULT

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Silvia Peter William, MPhil

  Ziauddin University, Karachi, Sindh, Pakistan

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Silvia Peter William, Mphil

CONTACT

021-36629251; williamsilviapeter@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: All participants will be blinded regarding treatment. A total of 38 patients will be recruited and assigned into two groups. Group A will receive Kinect Xbox game therapy exercises and Group B will receive Conventional Circuit Exercises
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Experimental Group Kinect game-based Rehabilitation: Device Kinect XBOX 360. Kinect game will be given 30 sessions, and intervention will run for 30 minutes (excluding rest period), five days a week, for six weeks, The patients will take 1-2 minutes rest after 5 minutes of activity. Placebo Comparator: Control Group: Conventional Rehabilitation: Conventional exercises will be given 30 sessions, and intervention will run for 30 minutes (excluding rest period), five days a week, for six weeks, The patients will take 1-2 minutes rest after 5 minutes of activity.

Study Record Dates

• First Submitted: June 23, 2026
• First Posted: June 29, 2026
• Study Start: June 24, 2026
• Primary Completion: July 15, 2026
• Study Completion (Estimated): August 15, 2026
• Last Updated: June 29, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)