Neurophysiology of Reward Signaling in Parkinson's Disease
2 other identifiers
interventional
75
1 country
1
Brief Summary
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable parkinson-disease
Started Sep 2024
Longer than P75 for not_applicable parkinson-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2024
CompletedFirst Submitted
Initial submission to the registry
February 6, 2026
CompletedFirst Posted
Study publicly available on registry
February 13, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 30, 2029
February 13, 2026
February 1, 2026
5.1 years
February 6, 2026
February 6, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Changes in caudate DLPFC beta coherence
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Changes in gambling task performance with neural stimulation
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Secondary Outcomes (1)
Change in beta power with neural stimulation
Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours
Study Arms (1)
Neural recordings and stimulation
EXPERIMENTALInterventions
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Eligibility Criteria
You may qualify if:
- Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- Planned clinical electrode trajectory that contacts caudate
- Age greater than or equal to 40
- Diagnosis of Parkinson's disease or other movement disorder
- Able to participate in intraoperative testing
- English speaking
You may not qualify if:
- Age less than 40
- Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sarah Bick
Vanderbilt University Medical Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Neurosurgery, Principal Investigator
Study Record Dates
First Submitted
February 6, 2026
First Posted
February 13, 2026
Study Start
September 1, 2024
Primary Completion (Estimated)
September 30, 2029
Study Completion (Estimated)
September 30, 2029
Last Updated
February 13, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share