NCT07407621

Brief Summary

The study compares the impact of isokinetic resistance training (RT) -induced neuromuscular adaptation following an 8-week short ECC ISO RT and CON ISO RT among obese, untrained women. The main question it aims to answer is: 1\. Does exercise-induced neuromuscular adaptation following progressive short ECC ISO RT, more effectively than CON ISO RT, among obese, untrained women? Researchers will compare drug ECCISO RT to a CONISO RT to see if ECCISO RT is more effective in inducing neuro-muscular adaptations in obese, untrained women. Participants will:

  1. 1.Train on isokinetic ECC or CON for 8 weeks
  2. 2.Visit the clinic twice for baseline and post tests

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
24

participants targeted

Target at below P25 for not_applicable obesity

Timeline
Completed

Started Jan 2025

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 2, 2025

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

February 3, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 12, 2026

Completed
17 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2026

Completed
Last Updated

February 12, 2026

Status Verified

February 1, 2026

Enrollment Period

1.2 years

First QC Date

February 3, 2026

Last Update Submit

February 9, 2026

Conditions

ObesityPhysical Inactivity

Keywords

EccentricCardiometabolicNeuromuscular adaptation

Outcome Measures

Primary Outcomes (9)

  • Maximal voluntary strength

    Changes in maximal voluntary strength

    8 weeks

  • Neural activation assessment

    Changes in neural activation during strength

    8 weeks

  • Fasting plasma glucose

    Changes in fasting plasma glucose

    8 weeks

  • Functional physical fitness (6-minute walking test)

    Changes in distance during 6-minute walking test

    8 weeks

  • Indirect calorimetry

    Changes in basal metobolic rate/ fat oxidation rate/ charbohydrate oxidation rate

    8 weeks

  • HDL cholesterol

    Changes in HDL cholesterol

    8-weeks

  • LDL cholesterol

    Changes in LDL cholesterol

    8-weeks

  • Total cholesterol

    Changes in total cholesterol

    8-weeks

  • Trigliceride

    Changes in triglyceride

    8-weeks

Secondary Outcomes (2)

  • Percentage of Body Fat

    8 weeks

  • Lean muscle mass

    8 weeks

Study Arms (2)

ECC ISO

EXPERIMENTAL

Eccentric Isokinetic Exercise

Other: ECC ISO

CON ISO

ACTIVE COMPARATOR

Concentric Isokinetic Exercise

Other: CON ISO

Interventions

ECC ISOOTHER

Eccentric Isokinetic Exercise

ECC ISO
CON ISOOTHER

Concentric Isokinetic Exercise

CON ISO

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Eumenorrheic women (reporting menstrual cycle between 21-35 days)
  • Age 25-45 y/o
  • BMI \> 23.0 kg/m2
  • Body fat percentage \> 30%
  • No lower limb orthopaedic injuries
  • Have not participated in any structured/ unstructured weight loss intervention in the past 12 months
  • Sedentary lifestyle (regular exercise \<1 hour per week)
  • Stable body weight (loss or gain of no greater than 2 kg)
  • Stable medication use for six months before enrolment

You may not qualify if:

  • smokers
  • taking supplements or medication known to affect REE (such as oral contraceptives)
  • severe medical conditions affecting their physical or mental health
  • individuals with an implanted medical device
  • suffer from alcohol or drug abuse
  • trying to conceive/ pregnant, or breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Community Health

Kepala Batas, Pulau Pinang, 13200, Malaysia

Location

Related Publications (7)

  • Peñailillo, L., Diaz-Reiher, M., Gurovich, A. and Flores-Opazo, M., 2022. A Short-Term Eccentric HIIT Induced Greater Reduction in Cardio-Metabolic Risk Markers in Comparison With Concentric HIIT in Sedentary Overweight Men. Research Quarterly for Exercise and Sport [online]. Available from: https://www.tandfonline.com/action/journalInformation?journalCode=urqe20.

    BACKGROUND

  • Paschalis, V., Nikolaidis, M. G., Theodorou, A. A., Panayiotou, G., Fatouros, I. G., Koutedakis, Y. and Jamurtas, A. Z., 2011. A Weekly Bout of Eccentric Exercise Is Sufficient to Induce Health-Promoting Effects. Medicine & Science in Sports Exercise [online], 43 (1), 64-73. Available from: http://www.acsm-msse.org [Accessed 19 Apr 2022].

    BACKGROUND

  • Julian, V., Thivel, D., Miguet, M., Pereira, B., Costes, F., Coudeyre, E., Duclos, M. and Richard, R., 2019. Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity. Scandinavian Journal of Medicine & Science in Sports [online], 29 (1), 4-15. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/sms.13301 [Accessed 19 Apr 2022].

    BACKGROUND

  • Pereira, B., Perrault, H., Duclos, M. and Richard, R., 2018. Eccentric Training Improves Body Composition by Inducing Mechanical and Metabolic Adaptations: A Promising Approach for Overweight and Obese Individuals. Frontiers in Physiology | www.frontiersin.org [online], 1, 1013. Available from: www.frontiersin.org.

    BACKGROUND

  • Jeon, S., Ye, X., Miller, W. M. and Song, J. S., 2022. Effect of repeated eccentric exercise on muscle damage markers and motor unit control strategies in arm and hand muscle. Sports Medicine and Health Science, 4 (1), 44-53.

    BACKGROUND

  • Coratella, G., Bollinger, L., Yan, X., Su, H., Liu, X., Gao, Y., Lu, J., Ma, Q., Shi, Y., Liu, J. and Xin, S., 2022. Effects of Different Resistance Exercise Forms on Body Composition and Muscle Strength in Overweight and/or Obese Individuals: A Systematic Review and Meta-Analysis. Frontiers in Physiology | www.frontiersin.org [online], 12, 791999. Available from: www.frontiersin.org.

    BACKGROUND

  • Chen, T. C., Hsieh, C.-C., Tseng, K.-W., Ho, C.-C. and Nosaka, K., 2017. Effects of Descending Stair Walking on Health and Fitness of Elderly Obese Women. Medicine and science in sports and exercise, 49 (8), 1614-1622.

    BACKGROUND

MeSH Terms

Conditions

ObesitySedentary Behavior

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior

Study Officials

  • Ahmad Munir Che Muhamed, PhD

    Universiti Sains Malaysia

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Mrs

Study Record Dates

First Submitted

February 3, 2026

First Posted

February 12, 2026

Study Start

January 2, 2025

Primary Completion

March 1, 2026

Study Completion

March 1, 2026

Last Updated

February 12, 2026

Record last verified: 2026-02

Locations

MY(1)