Study of the Impact of Microbial Exposure of the Habitat at the Time of Birth on the Development of Allergic Diseases.
Sponsor study identifier
observational
320
1 country
1
Study Start
November 12, 2019
Actual (reported)Primary Completion
December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
In 2001-2002, a longitudinal study on the risk of atopic sensitization in children was conducted by the Pneumo-Allergology and Pediatrics departments of the CHU Saint-Pierre Hospital and at the Neonatology Department of the Queen Fabiola Children's University Hospital (HUDERF). The aim of the study was to study bacteria and endotoxins in airborne dust in Brussels homes in order to evaluate their impact on the development of allergic diseases in newborns. Between December 2000 and August 2002, 114 children (67 from HUDERF and 47 from CHU St-Pierre) were included in the study. These were eutrophic children without acquired pathology or known genetics. Simultaneously a microbial habitat assessment was performed based on a detailed description and on endotoxin assays in the airborne and deposited dust (mainly mattress).These data can be used to define habitats with high or low contamination.Samples for microbial analyzes (Gram positive and negative and mold) were also carried out. Preliminary results suggested:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 12, 2019
Actual (reported)December 5, 2019
Actual (reported)December 9, 2019
Actual (reported)December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Prevalence of positivity of allergic skin tests
Prevalence of positivity of allergic skin tests
1 year
Prevalence of positivity of ImmunoCAP tests
Prevalence of positivity of ImmunoCAP tests
1 year
Prevalence of clinical manifestations of allergy
1 year
Prevalence of confirmed asthma
1 year
Spirometry results
1 year
Exhaled fraction of NO (FeNO) results
1 year
Eosinophilia count
1 year
Children who participated in the study conducted in 2001-2002, their parents and the siblings who were exposed to the same environment at this period.
The assessment is based on a comprehensive questionnaire, a simple clinical examination, an spirometry test, allergic skin tests, measurement of the exhaled fraction of NO (FeNO) and blood serum analysis.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Children who participated in the study conducted in 2001-2002, their parents and the siblings who were exposed to the same environment at this period.
CHU Brugmann
Brussels, 1020, Belgium
Olivier Michel, MD
CHU Brugmann
First Submitted
December 5, 2019
First Posted
December 9, 2019
Study Start
November 12, 2019
Actual (reported)Primary Completion
December 2022
Estimated (date passed)NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 19, 2022
Record last verified: 2022-07
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Source: ClinicalTrials.gov.
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