NCT07404059

Brief Summary

PURPOSE: This study will be conducted to investigate any significant effect of ultrasound fat cavitation or pneumatic compression on adipose tissue thickness in patients with lipedema. BACKGROUND: Lipedema is a connective tissue disorder that cause physical discomfort and psychological stress. A literature review published in 2020 estimated that 10-11% of women or approximately 400 million women across the globe have lipedema. Lipedema fat is dangerous when it progress onto abdomen and trunk resulting in a risk of developing high blood pressure, high cholesterol and diabetes. Ultrasound cavitation is a safe cosmetic procedure has almost no adverse reactions used to break down fat cells under the skin which improves the body shape and reduce circumference which make it a promising non invasive tool alternative to surgical liposuction. Pneumatic compression is bl=elieved to reduce the limb circumference and volume which make it a good treatment option for lipedema. HYPOTHESES: Null Hypothesis:there will be no significant effect of fat cavitation or pneumatic compression on the adipose tissue thickness in patients with lipedema. RESEARCH QUESTION:Will be any significant effect of fat cavitation or pneumatic compression on the adipose tissue thickness in patients with lipedema

Trial Health

55
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Trial Health Score

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Geographic Reach
1 country

1 active site

Status
unknown

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Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 4, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 11, 2026

Completed
Last Updated

February 11, 2026

Status Verified

February 1, 2026

First QC Date

February 4, 2026

Last Update Submit

February 4, 2026

Conditions

Lipedema

Keywords

pneumatic compressionfat cavitationlipedema

Interventions

fat cavitationDEVICE

fat cavitation is a device produces ultrasound waves used for fat lipolysis

Eligibility Criteria

Age30 Years - 45 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility Detailsfemales has lipedema as lipedema is affecting only females at periods of hormonal changes as puberty, pregnancy or menopause.
Age GroupsAdult (18-64)

You may qualify if:

  • Ninety females patients their age from 30 to 45 years
  • Diagnosed with mild to moderate lipedema
  • Mentally stable functionally and physically stable.

You may not qualify if:

  • Patents with severe lipedema
  • Patients with type 4 lipedema
  • Clinically unstable patients
  • Patients with chronic diseases
  • Patients with endocrine diseases
  • Patienst with similar conditions like lymphedema, dercum's diseases or overall obesity
  • Patients with lower limbs fractures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cairo University

Cairo, Egypt

AVAILABLE

MeSH Terms

Conditions

Lipedema

Condition Hierarchy (Ancestors)

Connective Tissue DiseasesSkin and Connective Tissue Diseases

Central Study Contacts

Heba abdo Badawy, phd

CONTACT

01025627635hopehope5@hotmail.com

Study Design

Study Type
expanded access
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

February 4, 2026

First Posted

February 11, 2026

Last Updated

February 11, 2026

Record last verified: 2026-02

Locations

EG(1)